宁心汤和疏肝汤分别配合富马酸喹硫平片治疗精神分裂症临床研究

Clinical Study on Ningxin Tang and Shugan Tang Respectively Combined with Quetiapine for Schizophrenia

目的:观察宁心汤配合富马酸喹硫平片、疏肝汤配合富马酸喹硫平片治疗精神分裂症的临床疗效。方法:将70例精神分裂症患者按随机数字表法分为试验A组和试验B组各35例。试验A组采用宁心汤配合富马酸喹硫平片进行治疗,试验B组采用疏肝汤配合富马酸喹硫平片进行治疗,治疗时间为3个月。采用精神分裂症阳性和阴性症状量表(PANSS)分析2组的临床疗效,采用副反应量表(TESS)分析药物的安全性。结果:试验A组总有效率为97.14%,试验B组为94.29%,2组比较,差异无统计学意义(P>0.05)。治疗前,2组PANSS总分、阴性症状评分、阳性症状评分、一般精神病理评分比较,差异均无统计学意义(P>0.05)。治疗后,2组PANSS总分、阴性症状评分、阳性症状评分、一般精神病理评分均较治疗前降低(P<0.05)。治疗后,2组PANSS总分、阴性症状评分、阳性症状评分、一般精神病理评分、TESS评分比较,差异无统计学意义(P>0.05)。结论:宁心汤配合富马酸喹硫平片、疏肝汤配合富马酸喹硫平片治疗精神分裂症的效果差异不大,都可以提高临床疗效,可在临床上推广。

Objective:To observe the clinical effect of Ningxin tang combined with quetiapine and Shugan tang combined with quetiapine respectively for schizophrenia.Methods:A total of 70 cases of patients with schizophrenia were divided into the experiment group A and the experiment group B according to the random number table method,35 cases in each group.The experiment group A was treated with Ningxin tang combined with quetiapine,and the experiment group B was treated with Shugan tang combined with quetiapine.Both groups were treated for three months.The clinical effect in the two groups was analyzed by Positive and Negative Symptom Scale(PANSS),and the safety of the medicine was analyzed by Treatment Emergent Symptom Scale(TESS).Results:The total effective rate was 97.14%in the experiment group A and 94.29%in the experiment group B,the difference being insignificant(P>0.05).Before treatment,compared the scores of PANSS,negative symptoms,positive symptoms and general psychopathology in the two groups,there was no significance in differences(P>0.05).After treatment,the above scores in the two groups were all decreased when compared with those before treatment(P<0.05).After treatment,compared the scores of PANSS,negative symptoms,positive symptoms,general psychopathology and TESS in the two groups,there was no significance in the difference(P>0.05).Conclusion:The therapy of Ningxin tang combined with quetiapine and that of Shugan tang combined with quetiapine have little difference in the effect on the treatment for schizophrenia,both of which can improve the curative effect and are worthy of clinical promotion.