青鹏软膏外涂联合冰片外敷治疗胺碘酮所致静脉炎临床研究

Clinical Study on Coating with Qingpeng Ointment Combined with External Applica tion with Borneol for Phlebitis due to Amiodarone

目的:观察青鹏软膏外涂联合冰片外敷治疗胺碘酮所致静脉炎的临床疗效。方法:选取本院治疗的静脉微泵胺碘酮后所致静脉炎的心率失常患者192例,按随机数字表法分为硫酸镁组(MS组)、青鹏软膏组(QP组)、冰片组(BO组)、青鹏软膏+冰片组(QP+BO组),每组48例。MS组给予50%硫酸镁溶液湿敷,QP组给予青鹏软膏局部涂抹,BO组给予冰片沙袋局部外敷,QP+BO组给予青鹏软膏外涂联合冰片外敷,均治疗1周。4组在治疗1 d、2 d、3 d、5 d、1周时评估疗效和患者患肢的疼痛评分。结果:QP+BO组在治疗2 d、3 d、5 d、1周时总有效率均高于MS组、QP组和BO组(P<0.05)。QP组在治疗1 d、2 d、3 d、5 d、1周时总有效率与MS组比较,差异均无统计学意义(P>0.05)。BO组在治疗1 d、2 d时总有效率与MS组比较,差异均无统计学意义(P>0.05)。BO组在治疗3 d、5 d、1周时总有效率均低于MS组(P<0.05)。治疗1 d、2 d、3 d、5 d、1周,QP+BO组疼痛评分均低于MS组、QP组和BO组(P<0.05)。QP组治疗1 d、2 d、3 d、5 d、1周时疼痛评分与MS组比较,差异均无统计学意义(P>0.05)。MS组治疗2 d、3 d、5 d、1周时疼痛评分均低于BO组(P<0.05)。结论:青鹏软膏外涂联合冰片外敷治疗胺碘酮所致静脉炎疗效优于50%硫酸镁溶液湿敷治疗。

Objective:To observe the clinical effect of coating with Qingpeng ointment combined with external application with borneol for phlebitis due to amiodarone.Methods:A total of 192 cases of patients with arrhythmia complicated with phlebitis due to micropump with amiodarone in our hospital were divided into the magnesium sulphate group(Group MS),the Qingpeng ointment group(Group QP),the borneol(Group BO)and the combination group(Group QP+BO)according to the random number table method,48 cases in each group.Group MS was given external application with 50%magnesium sulphate solution;Group QP was given local coating with Qingpeng ointment;Group BO was given local external application with sandbags with borneol;Group QP+BO was given coating with Qingpeng ointment combined with external application with borneol.All groups were treated for one week.On the 1^st,2^nd,3^rd,5^th and 7^th day of treatment respectively,the curative effect and the scores of pain of affected limbs were evaluated in the four groups.Results:On the 2^nd,3^rd,5^th and 7^th day of treatment,the total effective rates in the Group QP+BO were all higher than those in Group MS,Group QP and Group BO(P<0.05).On the 1^st,2^nd,3^rd,5^th and 7^th day of treatment,there was no significant difference being found in the comparison of the total effective rate between Group QP and Group MS(P>0.05).On the 1^st and 2^nd day of treatment,there was no significant difference being found in the comparison of the total effective rate between Group BO and Group MS(P>0.05);on the 3^rd,5^th and 7^th day of treatment,the total effective rates in Group BO were lower than those in Group MS(P<0.05).On the 1^st,2^nd,3^rd,5^th and 7^th day of treatment,the scores of pain in Group QP+BO were all lower than those in Group MS,Group QP and Group BO respectively(P<0.05).On the 1^st,2^nd,3^rd,5^th and 7^th day of treatment,there was no significant difference being found in the comparison of the score of pain between Group QP and Group MS(P>0.05).On the 2^nd,3^rd,5^th and 7^th day of treatment,the scores of pain in Group MS were lower than those in Group BO(P<0.05).Conclusion:In the treatment of phlebitis due to amiodarone,the therapy of coating with Qingpeng ointment combined with external application with borneol has better curative effect than wet dressing with 50%magnesium sulphate solution.