Schlafen家族蛋白在肿瘤和病毒感染中的研究进展

Progress of SLFN family proteins in tumor and virus infection

Schlafen(SLFN)家族基因是在人类与小鼠中首先被发现的具有调控细胞生长及T细胞分化等诸多生物学功能的重要基因。该家族基因在小鼠、马和人等各个物种中广泛存在并具有较高的同源性。研究表明,SLFN蛋白在抑制细胞增殖、驱动减数分裂、调控造血细胞、下调血小板数量及调节免疫应答等方面均起到重要的作用,同时还可抑制HIV-1和流感等病毒复制。此外,SLFN蛋白还被发现与肿瘤的治疗密切相关,可以作为预测肿瘤发展进程和化疗敏感性的分子标记。本文介绍了SLFN家族蛋白的分类、结构和主要特征、定位与功能,重点综述了其在肿瘤和病毒感染等相关领域的研究进展,以期为SLFN蛋白新功能的探究提供新思路,对蛋白发挥作用的可能机制给予提示,并为各相关领域的研究提供参考。

Schlafen(SLFN)family genes were initially found in humans and rats to regulate cell growth and T cell differentiation,and exist widely in mice,horses,humans and other species and exhibit high homology.Lines of evidence suggest that SLFN proteins play important roles in inhibiting cell proliferation,promoting meiosis,regulating hematopoietic cells,reducing platelet numbers and the immune response,and also exert antiviral functions against several virus species including HIV-1,influenza virus and others.In addition,SLFN proteins have also been found to be closely related to cancer therapy,and act as a molecular marker to predict tumor development and the sensitivity to chemotherapy drugs.In this review,we discuss the classification,structures,characteristics,location and functions of SLFN family proteins,and focus on progress related to tumor and virus infection,aiming to provide new thoughts on exploration of SLFN protein functions and the underlying mechanisms.