170例HIV感染孕妇的妊娠结局分析

Analysis on pregnancy outcomes of 170 HIV infected pregnant women

目的探讨并分析HIV感染孕妇的临床特征及妊娠结局。方法收集本院2007年1月—2018年11月期间HIV感染孕妇的流行病学资料,分析其流行病学特征以及妊娠结局。结果共纳入170例HIV感染孕妇,感染的主要方式为异性性传播。近3年诊治的HIV感染孕妇数量较前几年明显增多。孕妇的主要抗病毒方案为齐多夫定或替诺福韦+拉米夫定+洛匹那韦/利托那韦。婴儿主要抗病毒方案为齐多夫定或奈韦拉平。母婴阻断成功率100%。结论HIV感染孕妇数量呈上升趋势,及时对HIV感染孕妇进行规范系统的抗病毒治疗及对HIV暴露婴儿进行预防可有效阻断HIV母婴传播。

Objective To investigate and analyze the clinical features and pregnancy outcomes of HIV infected pregnant women.Methods Epidemiological data of HIV infected pregnant women in our hospital from January 2007 to November 2018 were collected,and their epidemiological characteristics and pregnancy outcomes were analyzed.Results A total of 170 HIV infected pregnant women were included.The main transmission pattern was heterosexual contact.The number of HIV infected pregnant women within the recent 3 years increased significantly compared with previous years.The main antiviral regimen for pregnant women was zidovudineor or tenofovir disoproxil fumarate+lamivudine+lopinavir/ritonavir.The main antiviral regimen for infants was zidovudin or nevirapine.The success rate of preventing the mother-to-child transmission was 100%.Conclusions The number of HIV infected pregnant women is on the rise.Timely and systemic antiretroviral therapy for HIV infected pregnant women,and prevention measures for HIV exposed infants can effectively block HIV mother-to-child transmission.