美托洛尔联合阿司匹林治疗急性心肌梗死的临床效果

Clinical effect of metoprolol combined with aspirin in the treatment of acute myocardial infarction

目的:探究美托洛尔联合阿司匹林治疗急性心肌梗死的临床效果。方法:2018年8月-2019年8月收治急性心肌梗死患者93例,随机分为两组。观察组采用美托洛尔联合阿司匹林治疗;对照组采用阿司匹林治疗。比较两组治疗效果。结果:观察组治疗总有效率及血管再通率均高于对照组,血管再闭塞发生率低于对照组,差异均有统计学意义(P<0.05)。观察组治疗后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板计数(PLT)、左室射血分数(LVEF)、左心室舒张末期内径(LVEDVI)、脑钠肽(BNP)等指标水平均优于对照组,差异有统计学意义(P<0.05)。结论:美托洛尔联合阿司匹林治疗急性心肌梗死疗效显著,可降低血管再闭塞发生率,LVEDVI和BNP水平下降,LVEF、PT和APTT升高,从而降低心血管事件发生率,提高患者生活质量。

Objective:To explore the clinical effect of metoprolol combined with aspirin in the treatment of acute myocardial infarction.Methods:From August 2018 to August 2019,93 patients with acute myocardial infarction were selected and randomly divided into two groups.The observation group was treated with metoprolol and aspirin;the control group was treated with aspirin.We compared the efficacy of the two groups.Results:In the observation group,the total effective rate and vascular recanalization rate were higher than those in the control group,and the incidence of vascular recanalization was lower than that in the control group,the difference was statistically significant(P<0.05).In the observation group,PT,APTT,PLT,LVEF,LVEDVI and BNP were all better than those in the control group,the difference was statistically significant(P<0.05).Conclusion:The clinical effect of metoprolol combined with aspirin in the treatment of acute myocardial infarction is significant,it can reduce the incidence of revascularization,reduce the levels of LVEDVI and BNP,increase LVEF,PT and APTT,reduce the incidence of cardiovascular events,and improve the quality of life of patients.