黄体酮联合甲状腺片治疗卵巢早衰的疗效观察

Therapeutic Effect of Progesterone Combined with Thyroid Tablets on Premature Ovarian Failure

目的观察黄体酮联合甲状腺片治疗卵巢早衰的疗效。方法选取我院卵巢早衰患者76例(2017年3月至2018年5月),随机分为黄体酮治疗的对照组(38例)与黄体酮联合甲状腺片治疗的观察组(38例),观察患者卵巢功能指标水平变化、治疗效果、生活质量及心理状态。结果治疗后,观察组LH(31.22±6.47)IU/L,FSH(21.74±3.19)IU/L,E2(59.80±12.22)μg/L,改善情况好于对照组,P<0.05,观察组治疗有效率92.11%,高于对照组,P<0.05,观察组社会功能(80.34±3.38)分,躯体功能(82.34±3.15)分,心理功能(84.22±3.27)分,物质生活(84.38±3.54)分,高于对照组,P<0.05,观察组SAS评分(48.33±1.36)分,SDS评分(46.56±1.68)分,低于对照组,P<0.05。结论给予卵巢早衰患者黄体酮联合甲状腺片治疗,能改善患者卵巢功能指标水平,提高患者生活质量,减轻不良心理状态,取得了较好的治疗效果,值得借鉴。

Objective To observe the efficacy of progesterone combined with thyroid tablets in the treatment of premature ovarian failure.Methods 76 patients with premature ovarian failure in our hospital(March 2017 to May 2018)were randomly divided into the control group(38 cases)treated with progesterone and the observation group treated with progesterone combined with thyroid tablets(38 cases).Observe the changes of ovarian function index,treatment effect,quality of life and mental state.Results After treatment,the observation group LH(31.22±6.47)IU/L,FSH(21.74±3.19)IU/L,E2(59.80±12.22)μg/L,the improvement was better than the control group,P<0.05,observation group The effective rate of treatment was 92.11%,which was higher than that of the control group,P<0.05.The social function of the observation group(80.34±3.38),the body function(82.34±3.15),the psychological function(84.22±3.27),and the material life(84.38±3.54),higher than the control group,P<0.05,the observation group SAS score(48.33±1.36)points,SDS score(46.56±1.68)points,lower than the control group,P<0.05.Conclusion The treatment of progesterone combined with thyroid tablets in patients with premature ovarian failure can improve the ovarian function index,improve the quality of life of patients,alleviate the bad mental state,and obtain a better therapeutic effect.It is worth learning.