替吉奥联合奥沙利铂在晚期结肠癌化疗中的临床效果及不良反应观察

Clinical Effects and Adverse Reactions of Teggio combined with Oxaliplatin in Advanced Colon Cancer Chemotherapy

目的研究晚期结肠癌化疗治疗中采用替吉奥联合奥沙利铂的临床效果及不良反应。方法以我院于2018年8月至2019年8月期间收治的64例晚期结肠癌患者作为研究对象,依据病例单双号随机分为研究组和对照组,两组患者数量均为32例,对照组患者仅采取奥沙利铂治疗,研究组患者采取替吉奥联合奥沙利铂治疗,研究比较两组患者的临床治疗效果、负性情绪评分、生活质量评分,不良反应发生率。结果研究组32例患者中显效14例、有效13例、无效5例,总有效率为(84.4%);对照组显效11例、有效9例、无效12例,总有效率为(62.5%),研究组由于对照组,χ^2值为3.924,P值为0.047(P<0.05)。治疗前两组患者的负面情绪评分无差异(P>0.05);经过一定的治疗,研究组患者的HAMA和HAMD评分均明显低于对照组,检验结果呈现差异具有显著性(P<0.05)。研究组患者生活中的躯体功能、心理功能、社会功能、物质生活评分均明显高于对照组,检验结果呈现差异具有显著性(P<0.05)。研究组恶心呕吐4例、骨髓抑制1例、外周神经毒性1例、肝肾功能损害2例研究组不良反应发生率为(23.5%),对照组恶心呕吐5例、骨髓抑制4例、外周神经毒性4例、肝肾功能损害3例,不良反应发生率为(50.0%),χ^2值为4.266,P值为0.038(P<0.05)。结论晚期结肠癌化疗中采用替吉奥联合奥沙利铂治疗临床效果显著,不良反应发生率低,值得临床推广应用。

Objective To study the clinical effects and adverse reactions of teggio combined with oxaliplatin in the treatment of advanced colon cancer.Methods Our hospital in August 2018-August 2019 admitted during the period of 64 cases of patients with advanced colon cancer as the research object,based on the cases of single and double were randomly divided into research group and the control group,two groups of patients number are 32 cases,control group patients only treated with oxaliplatin into,the team take gonow with oxaliplatin into therapy for patients with study compared two groups of patients with the clinical therapeutic effect,negative mood score,quality of life score,incidence of adverse reactions.Results Among the 32 patients in the study group,14 were effective,13 were effective and 5 were ineffective,with the total effective rate(84.4%).The total effective rate(62.5%)was 11,9 and 12,respectively,in the control group.There was no difference in the score of negative emotion between the two groups before treatment(P>0.05).After certain treatment,HAMA and HAMD scores of the experimental group were significantly lower than those of the control group,and the test results showed significant differences(P<0.05).The scores of physical function,psychological function,social function and material life in the study group were significantly higher than those in the control group,and the test results showed significant differences(P<0.05).Team of nausea and vomiting in 4 cases,bone marrow suppression in 1 case,1 cases of peripheral nerve toxicity,liver and kidney impairment,incidence of adverse reactions for 2 cases of group(23.5%),nausea and vomiting in 5 cases,4 cases were bone marrow suppression in the control group,4 cases were peripheral nerve toxicity,liver and kidney function damage in 3 patients,incidence of adverse reactions(50.0%),chi square value of 4.266,P value is 0.038(P<0.05).Conclusion The combination of teggio and oxaliplatin in the chemotherapy of advanced colon cancer has significant clinical effect and low incidence of adverse reactions.