抗生素降阶梯疗法治疗重症肺炎的疗效

Effect of Antibiotic Step Down Therapy on Severe Pneumonia

目的探究重症肺炎患者行抗生素降阶梯治疗的临床效果。方法择取2017年3月至2018年8月期间我院收治的82例重症肺炎患者为研究对象,根据患者入院时间先后顺序为依据分为对照组41例及观察组41例。对照组患者行常规抗生素疗法,观察组患者行抗生素降阶梯疗法,针对两组患者临床疗效、患者病死率、气管插管率以及不良反应发生率等指标进行比较,同时对比两组患者抗生素应用时间、临床症状消退时间以及住院时间等指标。结果观察组患者临床疗效90.24%显著高于对照组68.29%,患者病死率2.44%显著低于对照组14.63%,气管插管率29.27%显著低于对照组63.41%,不良反应发生率7.32%显著低于对照组24.39%,观察组患者抗生素应用时间、咳嗽及发热等临床症状消退时间以及住院时间均显著少于对照组,差异有统计学意义(P<0.05)。结论与传统抗生素升阶梯疗法相比,抗生素降阶梯治疗重症肺炎效果更理想,患者临床疗效更高,还可减少气管插管情况,规避死亡风险,同时可有效促进患者临床症状消退,减少抗生素应用时间,这对患者康复及生活质量提升均有积极影响,因此值得在临床中推广。

Objective To explore the clinical effect of antibiotic descending treatment in patients with severe pneumonia.Methods A total of 82 patients with severe pneumonia admitted to our hospital from March 2017 to August 2018 were enrolled.According to the order of admission,the patients were divided into 41 patients in the control group and 41 patients in the observation group.The patients in the control group underwent routine antibiotic therapy.The patients in the observation group underwent antibiotic descending therapy.The clinical efficacy,mortality,tracheal intubation rate and incidence of adverse reactions were compared between the two groups,and the antibiotic application time of the two groups was compared.Indicators such as clinical symptom regression time and hospitalization time.Results The clinical efficacy of the observation group was 90.24%significantly higher than that of the control group(68.29%),the patient mortality rate was 2.44%significantly lower than the control group 14.63%,the tracheal intubation rate was 29.27%significantly lower than the control group 63.41%,and the adverse reaction rate was 7.32%significantly lower.In the control group,24.39%,the antibiotic application time,cough and fever and other clinical symptoms disappeared and hospitalization time were significantly less than the control group,the difference was statistically significant(P<0.05).Conclusion Compared with the traditional antibiotic step-up therapy,the antibiotic descending step is more ideal for the treatment of severe pneumonia.The clinical efficacy of the patient is higher,the tracheal intubation can be reduced,the risk of death can be avoided,and the clinical symptoms can be effectively reduced and the antibiotics can be reduced.Application time,which has a positive impact on the rehabilitation of patients and quality of life,it is worth promoting in the clinic.