血浆同型半胱氨酸水平与脑梗死的相关性与临床检验学研究

Correlation between Plasma Homocysteine Llevel and Cerebral Infarction and Clinical Laboratory Study

目的研究分析血浆同型半胱氨酸水平与脑梗死的相关性与临床意义。方法选择脑梗死患者168例作为观察组,又根据发作情况分为首发组(40例)和复发组(44例)。体检正常者102例作为对照组,检测并对比组间空腹血浆同型半胱氨酸水平。结果观察组同型半胱氨酸血浆含量为(29.35±3.39)μmol/L,对照组为(12.15±1.66)μmol/L,两组比较差异有统计学意义(t=5.705,P<0.05);首发组与复发组比较,差异有统计学意义(t=-3.751,P<0.05)。在血浆同型半胱氨酸四个水平患者的百分率,复发组与首发组间差异均有统计学意义,中重度增高者(81.9%)明显高于首发组(45.0%)。结论高同型半胱氨酸血症与脑梗死有关,且水平越高,复发概率越大。

Objective To study the correlation and clinical significance of plasma homocysteine level with cerebral infarction.Methods A total of 168 patients with cerebral infarction were selected as the observation group,and were divided into the first group(40 cases)and the relapse group(44 cases)according to the onset.102 patients with normal physical examination were used as the control group,and the fasting plasma homocysteine levels between the groups were detected and compared.Results The plasma content of homocysteine in the observation group was(29.35±3.39)μmol/L,and that in the control group was(12.15±1.66)μmol/L.The difference between the two groups was statistically significant(t=5.705,P<0.05).The difference between the first group and the recurrent group was statistically significant(t=-3.751,P<0.05).The percentage of patients with plasma homocysteine levels was statistically significant between the recurrent group and the first group.The moderate to severe patients(81.9%)were significantly higher than the first group(45.0%).Conclusion Hyperhomocysteinemia is associated with cerebral infarction,and the higher the level,the greater the chance of recurrence.