草酸艾司西酞普兰治疗卒中后抑郁的临床效果

Clinical effect of escitalopram oxalate in the treatment of post-stroke depression

目的探讨草酸艾司西酞普兰治疗卒中后抑郁(PSD)的临床效果。方法选取我院收治的88例PSD患者,将其随机分为对照组(44例,氢溴酸西酞普兰片)和观察组(44例,草酸艾司西酞普兰片)。比较两组的治疗效果。结果治疗后,两组的5-HT水平均升高,S100-β及NSE水平均下降,且观察组优于对照组(P<0.05)。治疗后,两组的NIHSS评分均降低,且观察组明显低于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。观察组的不良反应总发生率明显低于对照组(P<0.05)。结论草酸艾司西酞普兰治疗PSD的临床效果显著,可改善患者血液相关指标及神经功能,且安全性高。

Objective To explore the clinical effect of escitalopram oxalate in the treatment of post-stroke depression(PSD).Methods A total of 88 PSD patients admitted in our hospital were selected and randomly divided into control group(44 cases,citalopram hydrobromide tablets)and observation group(44 cases,escitalopram oxalate tablets).The therapeutic effects of the two groups were compared.Results After treatment,the level of 5-HT in the two groups increased,the levels of S100-βand NSE in the two groups decreased,and those in the observation group were better than the control group(P<0.05).After treatment,NIHSS score in the two groups decreased,and that in the observation group was significantly lower than the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The total incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Escitalopram oxalate in the treatment of PSD has a significant clinical effect.It can improve the blood related indicators and neurological function of patients,and has high safety.