高剂量瑞舒伐他汀治疗急性心肌梗死的效果及对患者心肌纤维化及心室重构的影响

Effect of high-dose rosuvastatin in the treatment of acute myocardial infarction and its influences on myocardial fibrosis and ventricular remodeling of patients

目的探讨高剂量瑞舒伐他汀治疗急性心肌梗死的效果及对患者心肌纤维化及心室重构的影响。方法选定本院2016年7月至2018年10月收诊的102例急性心肌梗死患者,采用完全随机法将其分为观察组(51例)和对照组(51例)。观察组采用高剂量(20 mg/d)瑞舒伐他汀治疗,对照组采用低剂量(10 mg/d)瑞舒伐他汀治疗。比较两组半乳凝素-3(Gal-3)、基质金属蛋白酶-9(MMP-9)、白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、左心室射血分数(LVEF)、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、左室舒张期末内径(LVEDD)及左室收缩期末内径(LVESD)。结果治疗后,观察组Gal-3、MMP-9水平均低于对照组(P<0.05)。治疗后,两组IL-6、hs-CRP、TNF-α水平均降低,且观察组低于对照组(P<0.05)。治疗后,两组患者LVEF均升高,LVEDV、LVESV、LVEDD、LVESD均降低,且观察组LVEF高于对照组,LVEDV、LVESV、LVEDD、LVESD低于对照组(P<0.05)。结论高剂量瑞舒伐他汀可有效改善急性心肌梗死患者的心室重构及心肌纤维化,促进其心功能提升,值得推广应用。

Objective To investigate the effect of high-dose rosuvastatin in the treatment of acute myocardial infarction and its influences on myocardial fibrosis and ventricular remodeling of patients.Methods A total of 102 patients with acute myocardial infarction admitted in our hospital from July 2016 to October 2018 were selected,and the patients were divided into observation group(51 cases)and control group(51 cases)by complete random method.The observation group was treated with high-dose(20 mg/d)rosuvastatin,while the control group was treated with low-dose(10 mg/d)rosuvastatin.The galactosin-3(Gal-3),matrix metalloproteinase-9(MMP-9),interleukin-6(IL-6),high sensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),left ventricular ejection fraction(LVEF),left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV),left ventricular end diastolic diameter(LVEDD)and left ventricular end systolic diameter(LVESD)between the two groups were campared.Results After treatment,the levels of Gal-3 and MMP-9 in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of IL-6,hs-CRP and TNF-αin the two groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,LVEF of the two groups increased,LVEDV,LVESV,LVEDD and LVESD decreased,and LVEF of the observation group was higher than that of the control group,LVEDV,LVESV,LVEDD and LVESD were lower than those of the control group(P<0.05).Conclusion High-dose rosuvastatin can effectively improve ventricular remodeling and myocardial fibrosis in patients with acute myocardial infarction,and promote the cardiac function improvement,which is worthy of popularization and application.