地塞米松对口腔颌面部术后应激反应及炎症反应的影响

Effect of dexamethasone on stress and inflammation response after oral and maxillofacial surgery

目的分析地塞米松对口腔颌面部术后应激反应及炎症反应的影响。方法选取本院2018年6月至2019年6月收治的100例口腔颌面部手术患者,将其随机分为试验组(50例)和对照组(50例)。对照组患者术后予以常规处理,试验组患者在对照组基础上予以地塞米松。比较两组的应用效果。结果治疗3 d后,试验组血浆皮质醇、去甲肾上腺素水平、血清IL-1、IL-6、TNF-α水平、VAS评分均明显低于对照组(P<0.05)。试验组并发症总发生率明显低于对照组(P<0.05)。结论地塞米松应用于口腔颌面部术后,可有效减轻患者应激反应、炎症反应,降低并发症发生率。

Objective To analyze the effect of dexamethasone on stress and inflammation response after oral and maxillofacial surgery.Methods A total of 100 patients with oral and maxillofacial surgery admitted in our hospital from June 2018 to June 2019 were selected and randomly divided into experimental group(50 cases)and control group(50 cases).Patients in the control group received routine treatment after surgery,and patients in the experimental group received dexamethasone on the basis of the control group.The application effects of two groups were compared.Results After 3 days of treatment,the levels of plasma cortisol,norepinephrine,serum IL-1,IL-6,TNF-αand VAS score of the experimental group were lower than those of the control group(P<0.05).The total incidence of complications in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion Dexamethasone can effectively reduce the stress response,inflammatory response of patients after oral and maxillofacial surgery,and reduce the incidence of complications.