加味五虎追风散联合多巴丝肼对肾虚血瘀型帕金森病合并轻度认知障碍患者的临床疗效

Clinical effects of Supplemented Wuhu Zhuifeng Powder combined with levodopa and benserazide hydrochloride on patients with Parkinson’s disease and mild cognitive impairment due to Kidney Deficiency and Blood Stasis

目的 探讨加味五虎追风散联合多巴丝肼对肾虚血瘀型帕金森病合并轻度认知障碍患者的临床疗效.方法 144例患者随机分为对照组和观察组,每组72例,对照组给予多巴丝肼,观察组在对照组基础上加用加味五虎追风散,疗程3个月.检测统一帕金森病评定量表(UPDRS)评分、蒙特利尔认知评估量表(MoCA)评分、39项帕金森生存质量调查问卷(PDQ-39)评分、脑神经递质[5-羟色胺(5-HT)、乙酰胆碱(Ach)、多巴胺(DA)]S谱值、左旋多巴日用量、不良反应发生率变化.结果 治疗后,观察组UPDRS、PDQ-39评分及Ach低于对照组(P<0.05),MoCA评分、5-HT、DA更高(P<0.05).2组不良反应发生率比较,差异无统计学意义(P>0.05).结论 加味五虎追风散联合多巴丝肼能有效减轻肾虚血瘀型帕金森病合并轻度认知障碍患者认知功能损害,调控脑神经递质表达,延缓病情进展,改善生活质量,疗效确切,安全性较高.

AIM To explore the clinical effects of Supplemented Wuhu Zhuifeng Powder combined with levo dopa and benserazide hydrochloride on patients with Parkinson’s disease and mild cognitive impairment due to Kid ney Deficiency and Blood Stasis.METHODS One hundred and forty four patients were randomly assigned into control group(72 cases)for 3 month administration of levodopa and benserazide hydrochloride,and observation group(72 cases)for 3 month administration of both Supplemented Wuhu Zhuifeng Powder,levodopa and benseraz ide hydrochloride.The changes in unified Parkinson’s disease rating scale(UPDRS)score,Montreal Cognitive Assessment(MoCA)score,39 item Parkinson’s Disease Questionnaire(PDQ 39)score,S spectrum values of brain neurotransmitters[5 hydroxytryptamine(5 HT),acetyl choline(Ach),dopamine(DA)],daily dosage of levodopa and incidence of adverse reactions were detected.RESULTS After the treatment,the observation group demonstrated lower UPDRS,PDQ 39 scores and Ach than the control group(P<0.05),along with higher MoCA score,5 HT and DA(P<0.05).No obvious difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with Parkinson’s disease and mild cognitive impairment due to Kidney Deficiency and Blood Stasis,Supplemented Wuhu Zhuifeng Powder combined with levodopa and benserazide hydrochloride can effectively reduce cognitive function damage,regulate brain neurotransmitter expres sions,delay disease progression and improve life quality,with definite efficacy and high safety.