磁共振血氧水平依赖成像在糖尿病肾病的研究进展

Progress of blood oxygen level dependent MRI in diabetic kidney disease

糖尿病肾脏疾病(diabetic kidney disease,DKD)是严重的糖尿病慢性微血管并发症,也是导致终末期肾病的主要原因。早发现、早预防、早治疗有助于延缓DKD的进展。血氧水平依赖磁共振成像(blood oxygen level dependent MRI,BOLD-MRI)通过监测糖尿病患者肾脏氧代谢变化,在DKD的早期诊断、功能评估、预后判断及监测药物对DKD的影响中具有重要研究应用价值。作者就BOLD-MRI在糖尿病肾病中的研究应用进展进行综述。

Diabetic kidney disease(DKD) is a serious chronic microvascular complication of diabetes and a major cause of end-stage renal disease. Early detection, prevention and treatment can delay the progression of DKD. By monitoring the changes of renal oxygen metabolism in diabetic patients, blood oxygen level dependent MRI(BOLD-MRI) has important research and application value in the early diagnosis, functional evaluation, prognosis and monitor the effects of drugs on DKD. This article reviews the research progress and application of the BOLD-MRI in Diabetic Kidney Disease.