益肾通络方治疗缺血性脑小血管病伴非痴呆型血管性认知功能障碍的临床疗效观察

Clinical Effect of Yishen Tongluo Recipe on Ischemic Cerebral Vascular Disease with Non-dementia Vascular Cognitive Dysfunction

目的观察益肾通络方治疗缺血性脑小血管病伴非痴呆型血管性认知功能障碍(VCIND)的临床疗效。方法将符合诊断标准的80例缺血性脑小血管病伴VCIND病人随机分为治疗组和对照组,各40例。两组均给予常规治疗,对照组加用尼莫地平片,治疗组加用益肾通络方。观察并比较两组简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)及中医证候积分变化。结果治疗后,两组MMSE评分较治疗前均提高,差异无统计学意义(P>0.05),且治疗组与对照组比较差异无统计学意义(P>0.05)。治疗后,治疗组MoCA评分较治疗前提高(P<0.01),且治疗组高于对照组(P<0.05)。治疗后,两组中医证候积分较治疗前均降低(P<0.05),且治疗组优于对照组(P<0.05)。结论与单一使用西药治疗比较,益肾通络方治疗缺血性脑小血管病伴VCIND疗效更佳,在延缓病人注意力下降和执行功能障碍方面较优。

Objective To observe the clinical effect of Yishen Tongluo Recipe on ischemic cerebral vascular disease with non-dementia vascular cognitive dysfunction(VCIND).Methods Eighty patients of ischemic cerebrovascular disease with VCIND were randomly divided into the treatment group and control group,40 cases in each group.Routine treatment was given to both groups,nimodipine tablets were used in the control group,and Yishen Tongluo Recipe was used in the treatment group.Mini-mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA)and traditional Chinese medicine syndrome score were compared between two groups.Results After treatment,MMSE scores of two groups were increased compared with those before treatment(P>0.05),and the comparison between the treatment group and the control group was no significant(P>0.05).After treatment,MoCA score in the treatment group was higher than that before treatment(P<0.01),and the MoCA score in the treatment group was higher than that in the control group(P<0.05).After treatment,traditional Chinese medicine syndrome scores of two groups were lower than that before treatment(P<0.05),and traditional Chinese medicine syndrome scores in the treatment group was lower than that in the control group(P<0.05).Conclusion Compared with western medicine alone,Yishen Tongluo Recipe was more effective in the treatment of ischemic cerebrovascular disease with VCIND,especially in delaying the progression of attentional decline and executive dysfunction.