摘要
目的探究冠心病血瘀证与血管内皮功能及炎性因子的相关性。方法纳入2018年1月—2018年7月于中日友好医院中西医结合心内科住院治疗的冠心病病人180例(研究组)和55例非冠心病非血瘀证病人(对照组),收集病人中医四诊信息,检测血流介导的肱动脉血管舒张功能(FMD)、超敏C反应蛋白(hs-CRP)和生化指标,并进行冠心病血瘀证评分,根据积分高低分为高血瘀证积分组(56例)、低血瘀证积分组(62例)、非血瘀证组(62例)。结果FMD呈高血瘀证积分组<低血瘀证积分组<非血瘀证组<对照组递增的趋势(P<0.05);hs-CRP呈高血瘀证积分组>低血瘀证积分组>非血瘀证组>对照组递减趋势(P<0.05)。单因素线性回归分析结果显示FMD、hs-CRP与冠心病血瘀证积分相关(P<0.05);进一步多因素线性回归分析结果显示FMD[OR=-1.396,95%CI(-2.103,-0.689),P=0.000]、hs-CRP[OR=0.732,95%CI(0.460,1.003),P=0.004]与冠心病血瘀证积分依然存在相关性。结论血管内皮功能失调、机体炎症反应是冠心病病人血瘀证形成的病理学机制之一。
Objective To investigate the association of blood stasis syndrome with vascular endothelial function and inflammatory factors in coronary heart disease(CHD).Methods A total of 180 CHD patients(study group)and 55 patients with non-CHD and blood stasis syndrome who were not treated with CHD(control group)were enrolled.Data,blood flow-mediated brachial vasodilation(FMD),high-sensitivity C-reactive protein(hs-CRP)and biochemical indicators were measured.The blood stasis syndrome scores in CHD were recorded.According to the scores,the patients were divided into high blood stasis scores group(n=56),low blood stasis syndrome score group(n=62),and non-blood stasis syndrome group(n=62).Results FMD showed a increasing trendaney in high blood stasis syndrome score group,low blood stasis syndrome score group,non-blood stasis syndrome group,control group(P<0.05).Hs-CRP showed a decreasing trend aney in high blood stasis syndrome score group,low blood stasis syndrome score group,non-blood stasis group,and control group(P<0.05).Univariate linear regression analysis showed that FMD and hs-CRP were associated with CHD blood stasis syndrome scores(P<0.05).Further multivariate linear regression analysis showed FMD[r=-1.396,95%CI(-2.103,-0.689),P=0.000],and hs-CRP[OR=0.732,95%CI(0.460,1.003),P=0.004]is related to CHD blood stasis syndrome.Conclusion Vascular endothelial dysfunction and inflammatory response are the pathological mechanisms of blood stasis syndrome in patients with CHD.
作者
彭菊琴
张艺楠
彭娴
陈芳玲
李春岩
PENG Juqin;ZHANG Yinan;PENG Xian;CHEN Fangling;LI Chunyan(Institute of Basic Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中西医结合心脑血管病杂志》
2020年第7期1090-1095,共6页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
冠心病
血瘀证
血管内皮功能紊乱
炎症
coronary heart disease
blood stasis syndrome
endothelial dysfunction
inflammation