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联用小剂量阿立哌唑治疗女性精神分裂症代谢综合征临床观察 被引量:9

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摘要 由于精神分裂症患者本身的阴性症状和社会功能下降,患者常常生活懒散、久卧少动,这些不良生活方式使得其容易出现代谢相关问题[1]。越来越多的研究显示抗精神病药物尤其是一些非典型抗精神病药物可增加精神分裂症患者患代谢综合征代谢综合征(metabolic syndrome,MS)的风险。这种风险主要表现为体质量增加(腹型肥胖)、糖耐量异常(糖代谢调节异常)、高血压和脂代谢异常等,可使2型糖尿病、心脑血管疾病患病风险明显增高。女性患者由于其激素水平与男性患者存在明显不同,更容易发生代谢风险。代谢相关问题直接或间接影响了抗精神病药物疗效,也影响了患者治疗依从性,增加了治疗的风险,并成为精神分裂症不良预后的主要原因[2]。
出处 《中国药物与临床》 CAS 2020年第9期1503-1505,共3页 Chinese Remedies & Clinics
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