肺炎克雷伯菌耐药机制研究进展

Progress in the study of resistance mechanism of Klebsiella pneumoniae

肺炎克雷伯菌(Klebsiella pneumoniae,KP)是临床上感染性疾病重要的革兰阴性致病菌,可引起不同部位的感染,尤其是免疫缺陷患者、老年人和新生儿。由于抗生素耐药性的出现,致使肺炎克雷伯菌引起的院内感染的病程延长。随着肺炎克雷伯菌耐药率的迅速增加,给临床治疗带来了非常大的困难和挑战。本文通过对肺炎克雷伯菌常见的耐药机制的论述,以期提高临床医师对肺炎克雷伯菌的认识,为临床合理使用抗生素及预防和控制医院内感染提供理论依据。

OBJECTIVE Klebsiella pneumoniae(KP),an important gram-negative pathogen in clinical infectious diseases,can cause infection in different parts,especially in immunodeficient patients,the elderly and neonates.Nosocomial infection caused by K.pneumoniae have been prolonged due to the emergence of antibiotic resistance.The drug resistance rate of K.pneumoniae has been increasing rapidly,which brings great difficulties and challenges to clinical treatment.In this article,the common resistance mechanism of K.pneumoniae is reviewed,aiming to improve clinicians’understanding of K.pneumoniae,and provide theoretical basis for clinical rational use of antibiotics and prevention and control of nosocomial infection.