妊娠妇女合并阻塞性睡眠呼吸暂停低通气综合征的情况及其对不良妊娠结局的影响

Prevalence of complication of obstructive sleep apnea hypopnea syndrome and its effect on adverse pregnancy outcomes in pregnant women

目的探讨妊娠妇女合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的情况及其对不良妊娠结局的影响。方法回顾性分析1532例妊娠妇女的临床资料,统计其合并OSAHS及不良妊娠结局的发生情况,并比较正常妊娠结局和不良妊娠结局孕妇的一般人口学信息和临床特征。采用多因素Logistic回归模型分析妊娠合并OSAHS对不良妊娠结局的影响。结果1532例妊娠妇女中,共有299例(19.52%)合并OSAHS,418例(27.28%)出现不良妊娠结局。正常妊娠结局和不良妊娠结局孕妇在妇科疾病史、流产史、流产次数、是否合并OSAHS方面的差异均具有统计学意义(均P<0.05)。多因素Logistic回归分析结果显示,合并OSAHS是妊娠妇女发生不良妊娠结局的独立危险因素,合并OSAHS的孕妇发生不良妊娠结局的风险是不合并OSAHS孕妇的2.296倍(均P<0.05)。结论合并OSAHS在妊娠妇女中较为常见,其可增加不良妊娠结局的发生风险。

Objective To explore the prevalence of complication of obstructive sleep apnea hypopnea syndrome(OSAHS)and its effect on adverse pregnancy outcomes in pregnant women.Methods The clinical data of 1532 pregnant women were retrospectively analyzed.The incidence of complication of OSAHS and adverse pregnancy outcomes was counted.The general demographic information and clinical characteristics were compared between pregnant women with normal and adverse pregnancy outcomes.Multivariate Logistic regression model was used to analyze the impact of pregnancy complicated with OSAHS on adverse pregnancy outcomes.Results Among 1532 pregnant women,299(19.52%)cases were complicated with OSAHS,and 418(27.28%)cases suffered from adverse pregnancy outcomes.There was statistically significant difference between pregnant women with normal and adverse pregnancy outcomes in gynecological histories,history and frequency of abortion,and occurrence of complication of OSAHS(all P<0.05).Multivariate Logistic regression analysis results showed that complication of OSAHS was an independent risk factor for developing adverse pregnancy outcomes in pregnant women,pregnant women complicated with OSAHS had 2.296 times risk for developing adverse pregnancy outcomes than pregnant women without OSAHS(all P<0.05).Conclusion Complication of OSAHS is more common in pregnant women,and can increase the risk of developing adverse pregnancy outcomes.