口腔扁平苔藓患者焦虑抑郁与中医证型关系的分析

Analysis of the relationship between anxiety-depression and TCM syndrome types in patients with oral lichen planus

目的通过分析口腔扁平苔藓(OLP)患者焦虑、抑郁情绪与中医证型之间的关系,为探讨该病焦虑、抑郁情绪障碍患者的中医辨证论治提供临床资料。方法选择2018年1月~2019年5月本院口腔黏膜病专科门诊诊断为口腔扁平苔藓患者120例(包括糜烂型OLP 78例、非糜烂型OLP 42例),记录患者的一般信息,医院焦虑抑郁量表(HADS)评分及中医辨证分型。结果糜烂型口腔扁平苔藓患者和非糜烂型口腔扁平苔藓患者间焦虑、抑郁的发病率比较差异有统计学意义(χ^2=8.638,P<0.05;χ^2=5.065,P<0.05)。不同中医证型的OLP患者间焦虑、抑郁的发病率比较差异有统计学意义(χ^2=7.075,P<0.05;χ^2=6.904,P<0.05)。结论OLP患者中存在有焦虑抑郁的精神障碍,且在糜烂型口腔扁平苔藓患者中更明显。OLP伴焦虑抑郁状态的患者中以肝郁血瘀证最多见,其次为湿热内阻证者,阴虚内燥者较少。

Objective To provide clinical data for exploring traditional Chinese medicine syndrome differentiation and treatment of oral lichen planus(OLP)patients with anxiety and depression by analyzing the relationship between anxiety-depression and TCM syndrome types in OLP patients.Methods A total of 120 patients with OLP diagnosed in the oral mucosal disease clinic of our hospital from January 2018 to May 2019 were collected and divided into erosive OLP(n=78)and non-erosive OLP(n=42).The general information,hospital anxiety-depression scale(HADS)score and TCM syndrome differentiation and classification of patients were recorded.Results There were differences in the incidence of anxiety and depression between the two groups(χ^2=8.638,P<0.05;χ^2=5.065,P<0.05).There were significant differences in the incidence of anxiety and depression among OLP patients with different TCM syndrome types(χ^2=7.075,P<0.05;χ^2=6.904,P<0.05).Conclusion Anxiety-depression is present in OLP patients,and is more obvious in patients with erosive OLP.Among OLP patients with anxiety-depression,liver stagnation and blood stasis is the most common symptom,followed by damp-heat intemal resistance,and yin-deficiency with inner dryness is less common.