骨钙素与男性迟发性性腺功能减退症相关性的研究进展

Research progress on the correlation between osteocalcin and late-onset hypopogonadism in men

骨钙素(OC)是成骨细胞分化成熟后特异表达的标志蛋白,近年来研究显示,骨钙素除了在骨骼生长中起作用,还具有生物学活性,能够调节能量代谢和雄性生殖功能。男性迟发性性腺功能减退症(LOH)是指一种与男性年龄增长相关,以血清睾酮分泌减少为主要症状的临床综合征,除了性欲减退、性功能障碍等临床表现,也常伴有骨密度改变及代谢综合征等全身症状。本文综述了OC的分子生物学的特征和功能及其与LOH的相关性。

Osteocalcin(OC)is a marker protein that is specifically expressed after osteoblasts differentiation and maturation.Recent studies have shown that OC can not only exert its role in bone growth,but also has biological activity and can regulate energy metabolism and male reproductive function.Late-onset hypopogonadism(LOH)in men is a clinical syndrome that is related to the aging of men,with decreased serum testosterone secretion as the main symptom.In addition to clinical manifestations such as hyposexuality and sexual dysfunction,it is also often accompanied by systemic symptoms such as changes in bone density and metabolic syndrome.This paper reviews the molecular biology property and functions of OC and its correlation with LOH.