孕期间母亲合并甲状腺功能亢进症和服用抗甲状腺药物对新生儿甲状腺功能的影响

Effects of mother complicated with hyperthyroidism and taking antithyroid drugs on neonatal thyroid function during pregnancy

目的研究采用抗甲状腺药物(ATDs)治疗合并甲状腺功能亢进症(甲亢)的孕妇对新生儿甲状腺功能影响。方法从2017年3月~2019年5月本院接诊的孕期间合并甲状腺功能亢进症的孕妇中选取102例进行研究,根据治疗选用药物种类划分为研究组及常规组,每组51例,所有孕妇分娩出的新生儿根据产妇组别进行划分,观察比较新生儿甲状腺功能情况。结果将两组新生儿的TSH、FT4、FT3等多项甲状腺功能指标进行比较,研究组上述指标水平均显著优于常规组,差异有统计学意义(P<0.05);将两组患者的妊娠结局情况进行比较,研究组产儿的足月生产比例为78.43%,明显高于常规组,而研究组早产及剖宫产的比例分别为21.57%、19.61%,均明显低于常规组,差异有统计学意义(P<0.05);比较两组产妇的并发症、新生儿甲状腺功能异常等情况的发生率,研究组均远优于常规组,差异有统计学意义(P<0.05)。结论及时进行有效诊治可使合并甲状腺功能亢进症的孕期间母亲分娩出的新生儿发生甲状腺功能异常的可能性显著降低,改善新生儿出生质量,在临床治疗中具有较高应用价值。

Objective To investigate the effects of antithyroid drugs(ATDs)on the thyroid function of pregnant women complicated with hyperthyroidism during pregnancy.Methods 102 pregnant patients complicated with hyperthyroidism who visited our hospital from March 2017 to May 2019 were selected as the subjects of this study.The patients were divided into study group and conventional group according to the treatment medicine that was chosen,51 cases in each group.The neonates delivered by all pregnant women were divided according to the maternal groups,and the thyroid function of the neonates was observed and compared.Results The thyroid function indexes of TSH,FT4 and FT3 of the neonates in the two groups were compared.The above indexes of the study group were significantly better than those of the conventional group,and the differences were statistically significant(P<0.05).Comparing the pregnancy outcomes of the two groups of patients,the proportion of full-term births in the study group was 78.43%,which was significantly higher than that in the conventional group,while the proportion of premature delivery and cesarean section in the study group were 21.57%and 19.61%,respectively,which was significantly lower than that in the conventional group,the differences were statistically significant(P<0.05);The incidence of maternal complications and neonatal thyroid dysfunction in the two groups were compared,and the study group was far superior to the conventional group,with statistically significant differences(P<0.05).Conclusion Prompt and effective diagnosis and treatment can significantly reduce the possibility of thyroid dysfunction and improve the birth quality of neonates delivered by pregnant mothers complicated with hyperthyroidism,which have high application value in clinical treatment.