32例子宫肉瘤的临床病理分析及其与预后之间的关系

Clinicopathological analysis of 32 cases of uterine sarcoma and its relationship with the prognosis

目的探讨子宫肉瘤的临床病理分析及其与预后之间的关系,为子宫肉瘤患者的预后改进提供参考。方法选择2006年12月至2013年12月嘉兴市妇幼保健院诊治的32例子宫肉瘤患者为研究对象。对其子宫肉瘤的病理类型、病理分期和手术方式等进行观察,以此判断其与患者预后之间的关联。结果不同病理类型子宫肉瘤患者的3年生存率比较,其差异具有统计学意义;子宫肉瘤病理类型与疾病复发风险之间存在重要关联,不同手术方式患者的3年与5年生存率比较,其差异均具有统计学意义;相比之下,手术联合放疗与手术联合放化疗患者的3年生存率相对较高,两者5年生存率和绝经前后复发率比较,其差异均无统计学意义。结论子宫肉瘤患者在发病初期没有特异性的症状表现,将会极大地影响到临床诊断的精准度,而在手术前借助子宫内膜刮诊可以辅助确诊。不同病理类型子宫肉瘤与预后之间存在一定关联,制定治疗方案时应当综合考虑子宫肉瘤的病理类型。

Objective To analyze the clinical and pathological analysis of uterine sarcoma and its relationship with the prognosis,and to provide reference for the improvement of the prognosis of the patients with uterine sarcoma.Methods 32 cases of uterine sarcoma in Jiaxing Maternal and Child Health Hospital from December 2006 to December 2013 were used as the observation target,and the pathological type and the pathological stage and the operation mode of the patients were observed,to study the association between the patient′s prognosis and the clinical features.Results There was a significant difference in the 3-year survival rate of the patients with different pathological types of uterine sarcoma.There was a significant association between the pathological type of the uterine sarcoma and the risk of the recurrence of the disease,and there was a significant difference between the 3-year and the 5-year survival rates of the patients with different surgical methods.In contrast,the 3-year survival rate of combined radiotherapy and chemotherapy was relatively high,and there was no significant difference in 5-year survival rate and the recurrence rate before and after menopause.Conclusions In the early stage of the disease,uterine sarcoma has no specific symptoms.Therefore,the accuracy of clinical diagnosis will be greatly affected,so endometrial curettage can help confirm diagnosis before surgery.There is a certain correlation between different pathological types and prognosis,so the pathological type of uterine sarcoma should be comprehensively considered when formulating a treatment plan.