鼻塞式同步间歇正压通气(NIPPV)联合布地奈德雾化治疗新生儿急性呼吸窘迫综合征疾病的临床应用研究

Clinical application of nasal plug synchronous intermittent positive pressure ventilation(NIPPV)combined with budesonide atomization in the treatment of neonatal acute respiratory distress syndrome

目的:分析鼻塞式同步间歇正压通气(NIPPV)联合布地奈德雾化治疗ARDS(新生儿急性呼吸窘迫综合征)疾病的临床应用效果。方法:纳入病例是2017年5月—2019年11月收治的104例ARDS新生儿,随机平均分为两组。参照组52例采纳CPAP(持续气道正压通气通气)治疗,实验组52例采纳NIPPV+布地奈德雾化治疗,对比两组呼吸机通气时间、用氧时间、住院时间、血气指标以及并发症发生情况。结果:实验组呼吸机通气时间、用氧时间、住院时间均明显短于参照组,差异有统计学意义P<0.05;实验组治疗3 d后PaCO2明显低于参照组,实验组治疗3 d后PH以及PaO2明显高于参照组,差异有统计学意义P<0.05;实验组并发症发生率(3.85%,2/52)明显低于参照组(21.15%,11/52),差异有统计学意义P<0.05。结论:NIPPV+布地奈德雾化可有效缩短ARDS患者机械通气时间,改善血气指标,降低并发症发生率,值得借鉴。

Objective:To analyze the clinical effect of nasal plug synchronous intermittent positive pressure ventilation(NIPPV)+budesonide atomization in the treatment of ARDS(neonatal acute respiratory distress syndrome).Methods:104 neonates with ARDS admitted from May 2017 to November 2019 were randomly divided into two groups.52 children in the reference group were treated with CPAP(continuous positive airway pressure ventilation).52 patients in the experimental group were treated with NIPPV+budesonide atomization.The ventilation time,oxygen use time,hospitalization time,blood gas index and complications of the two groups were compared.Results:The ventilator ventilation time,oxygen use time and hospital stay time in the experimental group were significantly shorter than those in the reference group(P<0.05);the PaCO2 in the experimental group was significantly lower than that in the reference group(P<0.05);the pH and PaO2 in the experimental group were significantly higher than those in the reference group(P<0.05);the complication rate in the experimental group(3.85%,2/52)was significantly lower than that in the reference group(21.15%,11/52)There was statistical significance(P<0.05).Conclusion:NIPPV+budesonide atomization can effectively shorten the mechanical ventilation time of ARDS patients,improve the blood gas index and reduce the incidence of complications,which is worth learning.