基于临床实践的来曲唑促排卵方案综述

A review of letrozole in ovarian hyperstimulation based on clinical practice

来曲唑(letrozole,LE)可用于多囊卵巢综合征(polycystic ovary syndrome,PCOS)、卵巢低反应患者的治疗中,也可用于体外受精的辅助用药。与传统药物克罗米芬(clomiphene citrate,CC)相比,其具有半衰期短、促排卵效果更好、致畸率低等优势。但其具体使用方案在学术界尚无定论,本文从促排卵机制、使用剂量、用药时段、治疗天数、在不同体重指数患者中的应用等方面对来曲唑的应用方案的合理性进行简要综述。

Letrozole(LE) has been gradually applied to the treatment of patients with polycystic ovary syndrome(PCOS) and ovarian hyporesponsiveness, which is also used for auxiliary medication of in vitro fertilization. Compared with the traditional drug clomiphene citrate(CC), it has shorter half-life, better ovulation induction effect and lower teratogenic rate. However, its specific application scheme is still inconclusive. This article reviewed the rationality of the application scheme of letrozole from the following aspects: mechanism of ovarian hyperstimulation, dose, medication time, duration of treatment, application in patients with different body mass index.