乳酸脱氢酶在巨幼细胞性贫血诊断中的应用

Application of LDH in the Diagnosis of Megaloblastic Anemia

目的:分析乳酸脱氢酶在巨幼细胞性贫血诊断中的应用。方法:选取西安交通大学第一附属医院检验科2018年3月~2019年3月收治的200例巨幼细胞性贫血患者,将其设为观察组;200例骨髓异常增生症患者,设为对照组;分析比较两组患者的血象和乳酸脱氢酶,胆红素指标。结果:观察组中TBIL、DBIL、IBIL、LDH等指标均明显高于对照组,其中(t=6.59、4.31、6.43、6.57,P<0.05);观察组LDH升高的阳性率也大于对照组,其中(χ~2=10.98,P<0.05),差异均具有统计学意义。结论:乳酸脱氢酶在巨幼细胞性贫血的诊断中具有重要意义,是其诊断的主要参考指标。

Objective: To analyze the application of lactate dehydrogenase in the diagnosis of megaloblastic anemia. Methods: The patients admitted to the First Affiliated Hospital of Xi’an Jiaotong University from March 2018 to March 2019 were selected as subjects. Among them, 200 patients with megaloblastic anemia were included in the observation group;200 patients with abnormal bone marrow hyperplasia were set. The control group;blood and lactate dehydrogenase, bilirubin indicators were compared between the two groups. Results: The indexes of TBIL, DBIL, IBIL and LDH in the observation group were significantly higher than those in the control group,(t=6.59, 4.31, 6.43, 6.57, P<0.05). The positive rate of LDH elevation in the observation group was also higher than that in the control group.(χ~2=10.98, P<0.05), the difference was statistically significant. Conclusion: Lactate dehydrogenase is of great significance in the diagnosis of megaloblastic anemia and is the main reference for its diagnosis.