生血宁与多糖铁治疗血液透析患者肾性贫血的疗效比较

The difference of efficacy between Shengxuening and Polysaccharide iron complex capsule in treating renal anemia in patients with hemodialysis

目的比较生血宁片与多糖铁复合物对血液透析患者合并肾性贫血的疗效。方法选取2018年2月至2019年2月在合肥市第五人民医院血液净化中心进行规律性血液透析合并肾性贫血的患者50例,采用随机对照方法将该50例患者随机分为生血宁组(治疗组)和多糖铁组(对照组),每组25例。两组患者均按标准使用促红细胞生成素治疗,疗程12周,对照组在此基础上加用多糖铁复合物胶囊,治疗组在此基础上加用生血宁片。治疗组和对照组在治疗前、治疗12周均监测血红蛋白(Hb)、红细胞压积(hematocrit,Hct)、血清铁蛋白(serum ferritin,SF)、转铁蛋白饱含度(transferrin saturation,TSAT)等指标变化。结果治疗12周后对照组和治疗组分别与治疗前相比,血清Hb、Hct、SF、TAST均有明显升高(P<0.05);其中以治疗组升高更为明显,治疗组的血清Hb、Hct、SF、TAST水平显著高于对照组,差异有统计学意义(P<0.05)。结论生血宁片能够明显地提高血液透析患者体内的Hb、Hct、SF、TSAT,促进铁的吸收和利用,增加体内铁的储存,减少铁的消耗,其治疗维持性血液透析患者合并肾性贫血效果优于多糖铁复合物组。

Objective To investigate the difference of efficacy between Shengxuening and polysaccharide iron complex capsule in treating renal anemia in patients with hemodialysis.Methods A total of 50 cases of hemodialysis patients with renal anemia,who underwent hemodialysis regularly in blood purification center of Hefei Fifth People’s Hospital,were selected and randomly divided into observation group and control group,with 25 cases in each group.The treatment group was given Shengxuening tablets combined with erythropoietin and the control group given polysaccharide iron complex capsule combined with erythropoietin,with a treatment course of 12 weeks.Hemoglobin(Hb),hematocrit(Hct),serum ferritin(SF),and transferrin saturation(TSAT)were detected before treatment and at 4 weeks,8 weeks and 12 weeks of the treatment.Results After 12 weeks,the indices were compared between the control treatment and the treatment group.Serum Hb,Hct,SF and TAST all increased significantly(P<0.05).The changes of the indices were more obvious.Compared to the control group,serum Hb,Hct,SF and TAST in the treatment group had statistically significant changes after treatment(P<0.05).Conclusions Shengxuening tablets can significantly improve hemoglobin,hematocrit,SF and TSAT in hemodialysis patients,promote iron absorption and utilization,increase iron storage in the body,and reduce iron consumption.Its efficacy for treatment of treating renal anemia in hemodialysis patients by combing with erythropoietin is more evident than polysaccharide iron complex capsule combined with erythropoietin.