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前列地尔治疗冠心病心绞痛的效果探讨 被引量:1

Effect of Alprostadil on Angina Pectoris of Coronary Heart Disease
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摘要 目的:探讨前列地尔在冠心病心绞痛患者中的临床效果。方法:选择2017年6月-2018年3月笔者所在医院治疗的冠心病心绞痛患者132例作为研究对象,按照随机数字表法将其分为对照组和观察组,每组66例。对照组给予常规西药对症支持治疗,观察组在对照组基础上给予前列地尔治疗。比较两组临床疗效、炎症因子水平及不良反应发生情况。结果:观察组治疗总有效率为89.39%,高于对照组的74.24%,差异有统计学意义(P<0.05)。观察组治疗1个月后IL-6、Hcy、hs-CRP、sCD40L水平均低于对照组,差异有统计学意义(P<0.05)。两组治疗期间恶心呕吐、头晕、皮肤瘙痒、发热、腹泻、肝肾功能异常发生率比较差异均无统计学意义(P>0.05)。结论:将前列地尔用于冠心病心绞痛患者中效果显著,可改善患者炎症因子水平,药物安全性较高,值得推广应用。 Objective:To explore the clinical effect of Alprostadil in patients with angina pectoris of coronary heart disease.Method:A total of 132 patients with angina pectoris of coronary heart disease treated in our hospital from June 2017 to March 2018 were selected as the research subjects.According to the random number table method,they were divided into the control group and the observation group,with 66 cases in each group.The control group was given conventional western medicine symptomatic supportive treatment,and the observation group was given Alprostadil treatment on the basis of the control group.The clinical efficacy,levels of inflammatory factors and occurrence of adverse reactions were compared between the two groups.Result:The total effective rate was 89.39%in the observation group,which was higher than 74.24%in the control group,and the difference was statistically significant(P<0.05).The levels of IL-6,Hcy,hs-CRP,and sCD40 L in the observation group were lower than those in the control group after 1 month of treatment,the differences were statistically significant(P<0.05).There were no statistically significant differences in the incidence of nausea and vomiting,dizziness,skin pruritus,fever,diarrhea,and abnormal liver and kidney function between the two groups during treatment(P>0.05).Conclusion:The application of Alprostadil in patients with angina pectoris of coronary heart disease has significant effect,can improve the level of inflammatory factors in patients,and has high drug safety,which is worth popularizing.
作者 吴昆鹏 WU Kunpeng(Sinopharm Gezhouba Central Hospital,Yichang 443002,China)
出处 《中外医学研究》 2020年第12期55-57,共3页 CHINESE AND FOREIGN MEDICAL RESEARCH
关键词 前列地尔 冠心病 心绞痛 炎症因子 药物安全性 Alprostadil Coronary heart disease Angina pectoris Inflammatory factor Drug safety
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