大骨瓣减压术对颅脑损伤患者神经功能及预后的影响

The Effect of Decompression of Large Bone Flap on Neurological Function and Prognosis in Patients with Craniocerebral Injury

目的:探讨大骨瓣减压术对颅脑损伤患者神经功能及预后的影响。方法:选择2014年2月-2019年6月于笔者所在医院就诊的颅脑损伤患者60例,根据不同治疗方式将患者分为研究组(n=30)与对照组(n=30),研究组予以大骨瓣减压术治疗,对照组予以常规骨瓣开颅术治疗,比较两组神经功能及预后。结果:研究组治疗后血清IL-2、TNF-α水平均低于对照组,IL-4水平高于对照组,差异均有统计学意义(P<0.05)。研究组治疗后血清S100β、NSE水平及颅内压均低于对照组,差异均有统计学意义(P<0.05)。研究组NIHSS评分低于对照组,GCS评分、SF-36评分均高于对照组,差异均有统计学意义(P<0.05)。结论:大骨瓣减压术治疗可有效减轻颅脑损伤患者的炎症反应,降低血清S100β、NSE水平,降低颅内压,改善患者神经功能,提高患者的生活质量,治疗效果良好,值得推荐。

Objective:To investigate the effect of decompression of large bone flap on neurological function and prognosis in patients with craniocerebral injury.Method:A total of 60 patients with craniocerebral injury who were treated in our hospital from February 2014 to June 2019 were divided into the study group (n=30) and the control group (n=30) according to different treatment methods.The study group was treated with large bone flap decompression,and the control group was treated with conventional bone flap craniotomy,the neurological function and prognosis of the two groups were compared.Result:The serum levels of IL-2 and TNF-α in the study group were lower than those in the control group,the differences were statistically significant (P<0.05).The serum levels of S100 β,NSE and intracranial pressure in the study group were lower than those in the control group,the differences were statistically significant (P<0.05).The NIHSS score in the study group was lower than that in the control group,and the GCS score and SF-36 score were higher than those in the control group,the differences were statistically significant (P<0.05).Conclusion:Large bone flap decompression can effectively reduce the inflammatory response of patients with brain injury,reduce the serum S100β,NSE level,reduce intracranial pressure,improve the neurological function of patients,improve the quality of life of patients,and the treatment effect is good,which is worth recommending.