慢阻肺合并阻塞性睡眠呼吸暂停低通气综合征患者的危险因素分析

Analysis of risk factors in COPD patients with obstructive sleep apnea hypopnea syndrome

目的探讨慢性阻塞性肺疾病(COPD)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的危险因素。方法选取2016年6月-2018年6月在我院就诊的120例COPD患者,按照是否同时患有OSAHS分为重叠综合征组55例(COPD合并OSAHS),单纯COPD组65例,询问年龄、吸烟史、高血压病史、糖尿病史、肾功能不全、心脑血管病等,测量身高、体重,计算体重指数,分析2组患者的肺功能相关指标(FEV1/FVC、FEV1%)。结果单因素分析显示:肺功能、体重指数、合并原发性高血压、糖尿病、心脑血管病在重叠综合征组和单纯COPD组之间的差异有统计学意义(P<0.05)。Logisitc回归分析显示:体重指数是COPD合并OSAHS的独立危险因素之一。结论肥胖是影响COPD合并OSAHS的独立危险因素。

Objective To explore the risk factors of chronic obstructive pulmonary disease(COPD)with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods 120 cases of COPD patients in our hospital between June,2016 and June,2018 were enrolled,and were divided into overlap syndrome group(55 cases)and COPD group(65 cases)according to complication of OSAHS.The age,height,weight,smoking,primary hypertension,diabetes,renal insufficiency,Cardio and cerebro-vascular diseases in both groups were recorded and analyzed. Lung function index(FEV1/FVC%,FEV1%)were compared.Results Univariate analysis showed that BMI,pulmonary function,hypertension,diabetes,cardio and cerebro-vascular diseases were significantly different between the overlap syndrome group and the COPD group(P<0.05).Multivariate regression analysis showed that BMI was an independent risk factor for COPD in patients with OSAHS.Conclusion Obesity is an independent risk factor for COPD with OSAHS.