苓桂术甘汤对慢性心力衰竭患者血清TNF-αIL-10及TGF-β1水平的影响

Effect of Linggui Zhugan decoction on serum TNF-α,IL-10 and TGF-β 1 Levels in patients with chronic heart failure

目的观察苓桂术甘汤对慢性心力衰竭患者血清TNF-α、IL-10及TGF-β1水平的影响。方法将慢性心力衰竭患者60例随机分为观察组和对照组,每组30例。对照组应用常规治疗,观察组用常规治疗加苓桂术甘汤治疗,2周后检测血清TNF-α、IL-10及TGF-β1含量。结果与对照组相比,观察组患者TNF-α、TGF-β1水平降低,IL-10水平升高(P<0.05)。结论苓桂术甘汤可通过影响血清TNF-α、IL-10及TGF-β1水平治疗慢性心力衰竭,提高临床疗效。

Objective To observe the changes of serum TNF-α,IL-10 and TGF-β1levels in patients with chronic heart failure before and after treatment with Linggui Zhugan Decoction.Methods 60 patients with chronic heart failure were randomly divided into observation group and control group,30 cases in each group.The control group was treated with routine treatment,while the observation group was treated with routine treatment plus Linggui Zhugan Decoction.After 2 weeks,the levels of TNF-α,IL-10 and TGF-β1in serum were measured.Results Compared with the control group,Linggui Zhugan Decoction could decrease the levels of TNF-αand TGF-β1and increase the levels of IL-10(P<0.05).Conclusion Linggui Zhugan Decoction can improve the therapeutic effect of chronic heart failure by influencing the levels of TNF-α,IL-10 and TGF-β1 in serum.