NF-κB在糖尿病视网膜病变中的研究进展

A review on NF-kappa B in diabetic retinopathy

糖尿病视网膜病变(Diabetic Retinopathy,DR)的发病机制复杂,目前尚不明确,但其与炎症反应关系密切,核因子-κB(Nuclear Factor-kappa B,NF-κB)在炎症反应机制中具有重要作用,参与许多炎症因子基因的转录调节,表现于基因水平结合炎症因子,调控其表达,从而增加细胞凋亡速度,新生血管增生增多。故在此对NF-κB与糖尿病视网膜病变的关系进行探讨。

The pathogenesis of diabetic retinopathy is complicated and not completely clear,but it is closely related to its inflammation.NF-kB has important effects on the inflammation mechanisms of diabetic retinopathy.It participates in the transcriptional regulation of many inflammatory cytokine genes.Therefore,the relationship between NF-kappa B and diabetic retinopathy is discussed.