百合固金汤合止嗽散治疗肺癌咳嗽(肺阴亏虚证)的临床研究

Clinical study on Baihe Gujin decoction and Zhisou powder in treating lung cancer cough(lung yin deficiency syndrome)

目的观察百合固金汤合止嗽散治疗肺癌咳嗽(肺阴亏虚证)的临床疗效。方法选用2018年8月~2019年8月在常德市第一中医医院血液肿瘤科收治的肺癌患者60例作为研究对象,按照随机数字表法,随机分为治疗组(30例)和对照组(30例)。治疗组在西医治疗基础上加用百合固金汤合止嗽散治疗,对照组在西医治疗基础上加用磷酸可待因片治疗。两组均治疗14d后,比较两组治疗前后日间、夜间咳嗽症状评分和治疗前后中文版莱斯特咳嗽量表(LCQ-MC)评分。结果(1)治疗14d后,治疗组日间、夜间咳嗽症状评分均低于对照组,差异有统计学意义(P<0.05);(2)两组患者治疗14d后,治疗组生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论百合固金汤合止嗽散治疗肺癌咳嗽(肺阴亏虚证)疗效比磷酸可待因片疗效好。

Objective To observe the clinical effect of Baihe Gujin decoction combined with Zhisou powder in treating cough of lung cancer(lung yin deficiency syndrome).Methods Sixty patients with lung cancer treated in the department of hematology and oncology of Changde First Hospital of Traditional Chinese Medicine from August 2018 to August 2019 were selected as the research subjects.They were randomly divided into the treatment group(n=30)and the control group(n=30)according to the random number table method.The treatment group was given Baihe Gujin decoction and Zhisou powder based on western medicine treatment,while the control group was given codeine phosphate tablets based on western medicine treatment.After 14 days of treatment,the scores of day and night cough symptoms before and after treatment and Mandarin Chinese version of the Leicester Cough Questionnaire(LCQ-MC)score before and after treatment were compared.Results(1)After 14 days of treatment,the scores of cough symptoms during the day and night in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).(2)After 14 days of treatment,the quality of life score in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Baihe Gujin decoction and Zhisou powder are more effective than codeine phosphate tablets in the treatment of lung cancer cough(lung yin deficiency syndrome).