滋养层细胞表面抗原2和DNA甲基转移酶1在鼻咽癌中的表达及与其临床病理特征的相关性分析

Expression of Trophoblast Cell Surface Antigen 2 and DNA Methyltransferase 1 in Nasopharyngeal Carcinoma and Its Correlation with Clinicopathological Features

目的分析滋养层细胞表面抗原2(Trop2)和DNA甲基转移酶1(DNMT1)在鼻咽癌(NPC)中的表达及与其临床病理特征的相关性分析。方法回顾性分析本院2014年5月-2019年5月临床确诊的131例鼻咽癌患者的临床资料,对其癌组织及癌旁组织进行染色,检测Trop2及DNMT1的表达水平,并结合其鼻咽黏膜组织病理分期情况,分析Trop2、DNMT1的表达与其病理特征的相关性。结果 Trop2、DNMT1的阳性定位均于细胞膜,颜色自浅黄色至棕褐色不等,NPC癌组织中Trop2、DNMT1的高表达率显著高于癌旁组织(P<0.05);TNM分期处于Ⅲ~Ⅳ期、伴随淋巴结转移的NPC患者Trop2、DNMT1的表达更高(P<0.05);NPC患者的Trop2、DNMT1表达与其TNM分期、淋巴结转移程度呈正相关(P<0.05)。结论 NPC患者Trop2、DNMT1的表达与疾病严重程度具有相关性,Trop2、DNMT1表达水平越高,患者病情越严重。

Objective To analyze the expression of trophoblast cell surface antigen 2(Trop2) and DNA methyltransferase 1(DNMT1) in nasopharyngeal carcinoma(NPC) and its correlation with clinicopathological features. Methods The clinical data of 131 patients with NPC diagnosed clinically in our hospital from May 2014 to May 2019 were retrospectively analyzed. The cancer tissues and adjacent tissues were stained, and the expression levels of Trop2 and DNMT1 were detected. The pathological staging of nasopharyngeal mucosa in all patients was combined to analyze the correlation between the expression of Trop2, DNMT1 and pathological features. Results The positive localization of Trop2 and DNMT1 were in the cell membrane, and the color varied from light yellow to tan. The high expression rates of Trop2 and DNMT1 in cancer tissues of NPC were higher than those in adjacent normal tissues(P<0.05). The expression of Trop2 and DNMT1 in NPC patients with lymph node metastasis and in TNM stage Ⅲ to Ⅳ was higher(P<0.05). The expression of Trop2 and DNMT1 of NPC patients was positively correlated with TNM stage and lymph node metastasis(P<0.05). Conclusion The expression of Trop2 and DNMT1 in patients with NPC is correlated with the severity of the disease. The higher the expression of Trop2 and DNMT1, the more severe the patient’s condition is.