台州地区类风湿性关节炎合并间质性肺炎危险因素研究

Study on risk factors of rheumatoid arthritis complicated with interstitial pneumonia in Taizhou area

目的探讨类风湿性关节炎(RA)合并间质性肺炎(IP)的发病情况及相关的危险因素。方法回顾性分析2015年1月~2018年12月在我院住院的286例RA患者的临床资料及实验室检查结果。根据RA患者是否合并IP,分成RA合并IP组(RA-IP组)和单纯RA组(RA组)。并对RA-IP组及RA组患者相关资料进行比较,分析可能危险因素。结果单因素分析示,RA-IP组病程、发病年龄、WBC、CEA、CA199及CA125均显著高于RA组(P<0.05);进一步进行多因素Logistics回归分析后发现病程、发病年龄和CA199为RA患者并发IP的独立危险因素。结论发病年龄大、病程长和CA199水平升高是RA-IP患者的独立危险因素。

Objective To investigate the incidence and related risk factors of rheumatoid arthritis(RA)with interstitial pneumonia(IP).Methods The clinical data and laboratory results of 278 RA patients hospitalized in our hospital from January 2015 to December 2018 were retrospectively analyzed.According to whether the RA patients merged IP,they were divided into RA combined IP group(RA-IP group)and RA alone group(RA group).The data of patients in RAIP group and RA group were compared.The possible risk factors were analyzed.Results In the single factor analysis,the duration of disease,age of onset,WBC,CEA,CA199 and CA125 in the RA-IP group were significantly higher than those in the RA group(P<0.05).Further multivariate logistics regression analysis showed that the duration of disease,age of onset,and CA199 were independent risk factors for IP in patients with RA.Conclusion The high age of onset,long course of disease and elevated CA199 levels are independent risk factors for RA-IP patients.