阿托伐他汀对慢性硬膜下血肿患者钻孔术后的影响

Effects of atorvastatin on patients with chronic subdural hematoma after drilling

目的探讨阿托伐他汀对慢性硬膜下血肿患者钻孔术后临床疗效的影响。方法选择2014年1月~2019年5月于我院治疗的慢性硬膜下血肿患者63例,按治疗方式不同分为单纯手术组(行钻孔引流治疗,n=30)和联合治疗组(钻孔引流术后服用阿托伐他汀,n=33),对比分析两组患者的术后复发、并发症及术后1个月mRS评分等。结果联合治疗组术后有1例复发,单纯手术组有7例复发,联合治疗组术后血肿复发的风险低于单纯手术组(P=0.042<0.05);两组术后1个月mRS评分及并发症的发生率无显著差异(P>0.05)。结论慢性硬膜下血肿患者钻孔术后使用阿托伐他汀可明显降低术后血肿复发率,且不增加患者术后并发症。

Objective To investigate the effects of atorvastatin on the clinical efficacy of patients with chronic subdural hematoma after drilling. Methods 63 patients with chronic subdural hematoma who were treated in our hospital from January 2014 to May 2019 were selected, and divided into two groups according to different therapeutic regimens,namely the group treated by drilling and drainage alone(n=30) and the combination therapy group given atorvastatin after drilling and drainage(n=33). The postoperative recurrence, complications and 1 month postoperative mRS score were compared and analyzed between the two groups. Results There was 1 case of postoperative recurrence in the combination therapy group and 7 cases of postoperative recurrence in the group treated by drilling alone. The risk of postoperative hematoma recurrence in the combination therapy group was lower than that in the group treated by drilling alone(P=0.042<0.05). There were no significant differences in 1 month postoperative mRS score, mortality, and incidence of complications between the two groups(P>0.05). Conclusion The use of atorvastatin after drilling for patients with chronic subdural hematoma can significantly reduce the recurrence rate of postoperative hematoma, without increasing postoperative complications.