康复新液联合利多卡因辅助氧疗治疗复发性口腔溃疡的临床研究

Clinical study of Kangfuxin Liquid combined with lidocaine assisted oxygen therapy in the treatment of recurrent oral ulcer

目的探讨康复新液联合利多卡因辅助氧疗治疗复发性口腔溃疡的临床效果。方法选取复发性口腔溃疡患者107例,用随机数字表法随机分为对照组(53例)与研究组(54例),对照组给予利多卡因、氧疗治疗,研究组给予康复新液、利多卡因、氧疗治疗。于治疗后6天比较2组疼痛缓解程度,观察2组患者溃疡愈合时间,2组比较患者CD3^+、CD4^+、CD8^+、白细胞介素6(interleukin 6,IL-6)和肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)水平,随访观察2组溃疡复发状况及不良反应发生情况。结果治疗后,研究组疼痛指数低于对照组,愈合时间短于对照组,总有效率高于对照组,CD3^+、CD4^+、CD4^+/CD8^+高于对照组,TNF-α、IL-6水平低于对照组,复发率低于对照组(P<0.05或P<0.01)。2组不良反应发生率差异无统计学意义(P>0.05)。结论复发性口腔溃疡采用康复新液联合利多卡因辅助氧疗治疗可增强疗效,缓解疼痛,改善免疫功能,减轻炎症反应,降低复发率,且不良反应少。

Objective To investigate the clinical effect of Kangfuxin liquid combined with lidocaine assisted oxygen therapy on recurrent oral ulcer.Methods A total of 107 patients with recurrent oral ulcer were randomly divided into control group(53 cases)and study group(54 cases)by random number table method.The control group was treated with lidocaine and oxygen therapy,while the study group was treated with Kangfuxin solution,lidocaine and oxygen therapy.The pain relief degree of the two groups was compared 6 days after treatment.Six days after the treatment,the cure rate of the two groups was compared,the levels of CD3^+,CD4^+,CD8^+,IL-6 and TNF-αwere compared,and the recurrence and adverse reactions of the two groups were followed up.Results After treatment,the pain index of the study group was lower than that of the control group,the healing time was shorter than that of the control group,the total effective rate was higher than that of the control group,the levels of CD3^+,CD4^+and CD4^+/CD8^+were higher than that of the control group,the levels of TNF-αand IL-6 were lower than that of the control group,and the recurrence rate was lower than that of the control group(P<0.05 or P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of recurrent oral ulcer with Kangfuxin liquid combined with lidocaine adjuvant oxygen therapy can enhance the efficacy,relieve pain,improve the immune function,reduce the inflammatory response,reduce the recurrence rate,and have fewer adverse reactions.