老年急性脑梗死患者血清MMP-9 IL-17 hs-CRP的表达及与颈动脉粥样硬化斑块的关系研究

Expression of serum levels of MMP-9,IL-17 and hs-CRP in elderly patients with acute cerebral infarction and their relationship with carotid atherosclerotic plaque

目的探讨老年急性脑梗死(acute cerebral infarct,ACI)患者血清基质金属蛋白酶-9(MMP-9)、白介素-17(IL-17)、高敏C反应蛋白(hs-CRP)的水平与其颈动脉粥样硬化(carotid atherosclerosis,CAS)斑块的关系。方法选取2014-10-01—2015-09-30于郑州大学第一附属医院就诊的老年急性脑梗死患者180例为研究对象,设为实验组,采用多普勒超声检查对颈动脉斑块性质进行检查,分为稳定斑块组(70例)、不稳定斑块组(90例)和无斑块组(20例);另选取40例健康体检老人为健康对照组。采用酶联免疫吸附法(ELISA)对4组研究对象血清MMP-9、IL-17、hs-CRP水平进行检测。结果实验组斑块检出率为88.89%,高于对照组的30.00%,差异有统计学意义(P<0.05)。实验组血清MMP-9、IL-17、hs-CRP水平高于健康对照组,差异有统计学意义(P<0.05)。稳定斑块组、不稳定组血清MMP-9、IL-17、hs-CRP水平高于无斑块组,且不稳定组血清MMP-9、IL-17、hs-CRP水平高于稳定斑块组,差异均有统计学意义(P<0.05)。结论老年ACI患者血清MMP-9、IL-17、hs-CRP水平与其CAS斑块的性质存在一定关联,血清因子水平越高,患者CAS斑块稳定性越差,出现急性脑梗死的概率越高。

Objective To investigate the relationship between the levels of serum matrix metalloproteinase-9(MMP-9),interleukin-17(IL-17),high sensitive C-reactive protein(hs-CRP)and carotid atherosclerosis(CAS)plaque in elderly patients with acute cerebral infarction(ACI).Methods 180 patients with acute cerebral infarction who were treated in the First Affiliated Hospital of Zhengzhou University from October 1,2014 to September 30,2015 were selected as the study objects,and were set as the experimental group.The carotid plaque properties of the patients were examined by Doppler ultrasound,and they were divided into stable plaque group(70 cases),unstable plaque group(90 cases)and non plaque group(20 cases).Another 40 healthy old people were selected as the control group.The levels of MMP-9,IL-17 and hs-CRP were measured by enzyme-linked immunosorbent assay(ELISA).Results The plaque detection rate of the experimental group was 88.89%,which was higher than that of the control group(30.00%)(P<0.05).The levels of MMP-9,IL-17 and hs-CRP in the experimental group were higher than those in the healthy control group(P<0.05);the levels of MMP-9,IL-17 and hs-CRP in the stable plaque group and the unstable plaque group were higher than those in the non plaque group,and the levels of MMP-9,IL-17 and hs-CRP in the unstable plaque group were higher than those in the stable plaque group(P<0.05).Conclusion The levels of MMP-9,IL-17 and hs-CRP in elderly patients with ACI are related to the characteristics of CAS plaque.The higher the levels of these three serum factors,the worse the stability of CAS plaque,the higher the probability of acute cerebral infarction.