脑梗死患者血清Hcy MMP-9和ApoE水平与认知功能障碍的相关性分析

Serum levels of Hcy,MMP-9 and ApoE in patients with cerebral infarction and its correlation with cognitive dysfunction

目的分析脑梗死患者血清Hcy、MMP-9和ApoE的水平与认知功能障碍的相关性。方法回顾分析新乡市中心医院2018-07-2019-01收治的90例脑梗死患者的临床资料,并选取同期进行健康体检者40例作对照,对所有研究对象基本情况进行收集,并进行抽血检查。对比不同人群血清中Hcy、MMP-9和ApoE的水平,分析其认知功能障碍发生情况,并探讨认知功能障碍者血清Hcy、MMP-9和ApoE水平与MoCA量表中各项目的相关性。结果梗死组血清中Hcy、MMP-9和ApoE水平显著高于健康组(P<0.05);根据MoCA评分,90例脑梗死患者中认知障碍占23.33%,无认知障碍占76.67%。认知障碍患者血清中Hcy、MMP-9和ApoE显著高于无认知障碍者(P<0.05),Spearman分析结果显示,存在功能认知障碍者血清Hcy、MMP-9和ApoE水平与MoCA量表总分、视空间执行能力、命名、注意力与计算力、语言、延迟回忆呈负相关(P<0.05)。结论脑梗死患者血清中Hcy、MMP-9和ApoE水平较高,与脑梗死患者出现认知功能障碍存在相关性,提示三者可作为脑梗死后出现认知功能障碍预测指标,可对患者预后及治疗效果进行评估。

Objective To analyze the serum levels of Hcy,MMP-9 and ApoE in patients with cerebral infarction and its correlation with cognitive dysfunction.Methods The clinical data of 90 patients with cerebral infarction admitted to our hospital from July 2018 to January 2019 were retrospectively analyzed.40 indivduals with healthy physical examination were selected at the same time,and the basic conditions of the patients were collected and blood tests were performed.To compare Hcy,MMP-9 and ApoE levels in serum of different people,to analyze the incidence of cognitive dysfunction of prognosis,and the relationship between Hcy,MMP-9 and ApoE levels in the serum of patients with cognitive dysfunction and the items in the MoCA scale was also discussed.Results The serum levels of Hcy,MMP-9 and ApoE in the infarction group were significantly higher than those in the healthy group(P<0.05).According to the MoCA score,90 patients with cognitive dysfunction after cerebral infarction were evaluated,including 23.33%patients with cognitive impairment,and 76.67%patients without cognitive impairment.The Hcy,MMP-9 and ApoE levels in the serum of patients with cognitive impairment were significantly higher than those without cognitive impairment(P<0.05).Spearman analysis showed that the serum levels of Hcy,MMP-9 and ApoE in patients with cognitive dysfunction were negatively correlated with the total score of MOCA scale,spatial execution ability,naming,attention and computational power,language,delayed recall(P<0.05).Conclusion Hcy,MMP-9 and ApoE have higher levels in serum of patients with cerebral infarction,which has some correlation with cognitive dysfunction of patients.It suggests that them can be used as predictors of cognitive dysfunction after cerebral infarction to assess the prognosis and treatment effect of patients.