抗磷脂抗体和子痫前期的研究进展

Progress in research of antiphospholipid antibodies in preeclampsia

抗磷脂抗体是一类能与磷脂或磷脂结合蛋白结合的自身免疫性抗体,与血栓形成、不良孕产史密切相关。抗磷脂抗体中高滴度阳性的患者易有子痫前期等不良妊娠结局。子痫前期发生于妊娠期,可导致全身多脏器的损伤,严重危及母儿生命和健康。子痫前期的发病机制目前还不是很清楚,研究提示抗磷脂抗体可能通过诱导氧化应激,促进血管内炎症等作用参与子痫前期的发病;对于抗磷脂抗体阳性的患者,早期发现和早期干预对获得良好的妊娠结局至关重要。

Antiphospholipid antibodies are a class of autoimmune antibodies that bind to phospholipids or phospholipid-binding proteins and are closely related to thrombosis and poor maternal history.Patients with high levels of antiphospholipid antibodies are prone to adverse pregnancy outcomes such as preeclampsia.Preeclampsia occurs in pregnancy and can cause multiple organ damage with severe life-threatening complications in the mother and child.The pathogenesis of preeclampsia is still not clear.Studies suggest that antiphospholipid antibodies may participate in the pathogenesis of preeclampsia by inducing oxidative stress and promoting intravascular inflammation.Early detection and early intervention for patients with antiphospholipid antibodies are essential for achieving a good pregnancy outcome.