摘要
以邻苯二甲酸二乙酯为原料,经Claisen酯缩合反应、酸性酯水解反应、热脱羧反应、亚硝化反应、脱肟反应、羰基还原反应、Aldol反应、邻二醇氧化裂解反应制备了水合茚三酮,对各步的反应机理进行了详细的讨论。
Ninhydrin was synthesized from diethyl benzene-1,2-dicarboxylate via Claisen condensation, hydrolysis, decarboxylation, nitrosation, deoximation, reduction, oxidation reaction and the possible reaction mechanisms for every unit reactions are discussed.
作者
张曼
周俊豪
华宇成
任相伟
赵温涛
张万东
Man Zhang;Junhao Zhou;Yucheng Hua;Xiangwei Ren;Wentao Zhao;Wandong Zhang(School of Science,Tianjin University,Tianjin 300354,P.R.China;National Demonstration Center for Experimental Chemistry&Chemical Engineering Education(Tianjin University),Tianjin 300354,P.R.China;National Virtual Simulation Experimental Teaching Center for Chemistry&Chemical Engineering Education(Tianjin University),Tianjin 300354,P.R.China)
出处
《大学化学》
CAS
2020年第3期82-88,共7页
University Chemistry
关键词
水合茚三酮
邻苯二甲酸二乙酯
机理
2,2-Dihydroxyindane-1,3-dione(Ninhydrin)
Diethyl benzene-1,2-dicarboxylate
Mechanism
