阿司匹林联合氯吡格雷治疗进行性脑卒中的效果评价

Clinical effect of aspirin combined with clopidogrel in treatment of progressive stroke

目的观察进行性脑卒中患者使用阿司匹林联合氯吡格雷治疗的临床效果。方法选取2015年6月—2016年6月某医院收治的进行性脑卒中患者108例作为研究对象,依据随机数表法分为对照组和观察组,每组各54例。对照组使用阿司匹林药物进行治疗,观察组则使用阿司匹林联合氯吡格雷药物进行治疗,经过2周治疗后,对比两组患者临床疗效、神经功能缺损程度、日常自理能力以及不良反应。结果治疗后,观察组患者治疗总有效率(96.30%)高于对照组(83.33%),神经功能缺损程度评分(4.91±1.01)低于对照组(7.69±1.97),生活自理能力评分(86.52±4.36)高于对照组(74.69±4.83),不良反应发生率(7.41%)低于对照组(25.93%,P<0.05)。结论进行性脑卒中患者在接受氯吡格雷联合治疗后,临床效果显著提高,神经功能缺损程度降低,日常自理能力提高,不良反应较少。

Objective To investigate the clinical effect of aspirin combined with clopidogrel in the treatment of progressive stroke.Methods A total of 108 patients with progressive stroke from June 2015 to June 2016 were randomly divided into a control group(n=54)and a trial group(n=54).The control group was treated with aspirin,while the trial group was treated with aspirin combined with clopidogrel.After 2 weeks of the treatment,the clinical efficacy,degree of neurological deficit,daily self-care ability,and adverse reactions were observed,analyzed,and compared between the two groups.Results After the treatment,the total effective rate of the trial group was 96.30%,which was higher than that of the control group(83.33%).The score of the degree of neurological deficit of the trial group was(4.91±1.01),which was lower than that of the control group(7.69±1.97).The score of daily self-care ability of the trial group was(86.52±4.36),which was significantly higher than that of the control group(P<0.05),and the incidence of adverse reactions of the trial group was 7.41%,which was lower than that of the control group(25.39%)(P<0.05).Conclusion After the treatment of aspirin combined with clopidogrel,the clinical effect of patients with progressive stroke is significantly improved,the degree of neurological deficit is decreased,the ability of daily self-care is improved,and the adverse reactions are few.