盐酸纳布啡复合丙泊酚麻醉对人工流产术患者疗效及安全性评价

Effect and safety of anesthesia of nalbuphine hydrochloride combined with propofol on patients undergoing artificial abortion

目的探讨盐酸纳布啡复合丙泊酚麻醉对人工流产术患者疗效及安全性评价。方法选择2018年1月—2019年1月某医院接收的人工流产术患者110例作为研究对象,随机数表法分为对照组和观察组,各55例。对照组采用生理盐水及丙泊酚行静脉注射,观察组采用盐酸纳布啡复合丙泊酚行静脉注射,比较两组患者丙泊酚平均用量、苏醒时间、视觉模拟量表(VAS)评分及不良反应。结果观察组丙泊酚平均用量、苏醒时间分别为(2.53±0.56)mg/kg、(6.17±1.35)min,小于对照组的(3.24±0.78)mg/kg、(8.21±1.46)min,差异有统计学意义(P<0.05);苏醒后5 min、15 min、30 min、60 min的VAS评分分别为(5.61±1.04)、(2.43±0.82)、(1.83±0.72)、(1.08±0.57)分,均低于对照组的(5.61±1.04)、(4.79±0.87)、(3.26±0.79)、(1.74±0.63)分,(P<0.05);观察组不良反应发生率为9.09%,对照组为14.55%,差异无统计学意义(P>0.05)。结论盐酸纳布啡复合丙泊酚对人工流产术患者的麻醉效果较好,可缩短苏醒时间,缓解子宫收缩疼痛,值得推广应用。

Objective To investigate the effect and safety of anesthesia of nalbuphine hydrochloride combined with propofol on patients undergoing artificial abortion.Methods A total of 110 patients undergoing artificial abortion in a hospital from January 2018 to January 2019 were randomly divided into a control group(n=55)and trial group(n=55).The control group was injected intravenously with saline and propofol,and the trial group was injected intravenously with nalbuphine hydrochloride combined with propofol.The dosage of propofol,recovery time,visual analog scale(VAS)score and adverse reactions were investigate and compared between two groups.Results In the trial group,the propofol dosage and recovery time were(2.53±0.56)mg/kg and(6.17±1.35)min,respectively,which were less/shorter than those in the control group(P<0.05).In the trial group,the VAS scores in 5 min,15 min,30 min,and 60 min were(5.61±1.04)points,(2.43±0.82)points,(1.83±0.72)points,and(1.08±0.57)points respectively,which were less than those in the control group[(5.61±1.04)points,(4.79±0.87)points,(3.26±0.79)points,and(1.74±0.63)points,respectively](P<0.05).The incidence of adverse reactions in the trial group was 9.09%,which was lower than that in the control group(14.55%),but the difference was not statistically significant(P>0.05).Conclusion Nalbuphine hydrochloride combined with propofol has a good anesthetic effect on patients undergoing artificial abortion,which can shorten the recovery time,relieve uterine contraction pain,and is safe,so it is worth popularizing and applying.