1例耐碳青霉烯类肺炎克雷伯菌腹腔感染患者的个体化治疗实践

Therapeutic Practice of Individualized Treatment in a Patient with Intra-abdominal Infection Caused by Carbapenemresistant Klebsiella Pneumoniae

以1例腹腔术后耐碳青霉烯类肺炎克雷伯菌(CR-KP)感染的患者为例,探讨临床药师在CR-KP感染个体化治疗中的作用。临床药师全程参与CR-KP腹腔感染患者的治疗并进行全面的药学监护,根据患者的病情变化和实验室检查结果,结合临床实践经验和药动学/药效学(PK/PD)理论,协助医师调整优化给药方案。通过对患者的治疗方案的优化,患者的感染得到控制。对于CR-KP腹腔感染,及时有效治疗、联合用药及优化抗感染治疗方案对控制感染非常重要。临床药师应发挥专业优势,积极参与抗感染治疗方案的制定、优化及开展药学监护工作。

To explore the role of clinical pharmacist in the individualized treatment for patients with infections caused by carbapenemresistant Klebsiella pneumonia(CR-KP),using a case of intra-abdominal infection caused by CR-KP after abdominal operation.Clinical pharmacist was involved in the treatment of intra-abdominal infection caused by CR-KP and provided the full range of clinical pharmacy services,assisting phyicians to optimize the medication regimen,on the basis of the patient’s condition and laboratory results,combined with clinical practice and PK/PD theory.The infection was effectively controlled by optimiazing the medication regimen.For infections caused by CR-KP,timely and effectively treatment,combination of drugs and optimization of treatment plan are important for infection control.Clinical pharmacists should exert the preponderance,actively participate in the establishing,optimization of anti-infection plan and carrying out pharmaceutical care.