红细胞分布宽度与急性胰腺炎严重程度的研究

Study of Red Blood Cell Distribution Width in Assessing the Severity of Acute Pancreatitis

目的研究外周血红细胞分布宽度(RDW)对急性胰腺炎AP严重程度评估的价值。方法收集2017年1月-2019年3月在首都医科大学大兴医院收治的急性胰腺炎(AP)患者266例,按疾病严重程度分为重症急性胰腺炎(SAP)组、中重症急性胰腺炎(MSAP)组、轻症急性胰腺炎(MAP),并纳入相同例数的健康体检者作为对照组,收集患者的一般资料及RDW进行统计分析。结果急性胰腺炎(AP)组与对照组之间RDW差异具有有统计学意义(P<0.05);SAP患者的RDW水平明显高于非SAP患者;RDW(P <0.05,OR=3.378)是急性胰腺炎的一项独立危险因素;ROC曲线预测AP及SAP曲线下面积分别为0.712及0.840。结论 RDW水平是评估急性胰腺炎严重程度及预后的一项有效指标。

Objective To investigate the value of red blood cell distribution width(RDW) in the patients with acute pancreatitis(AP) and its correlation with assessment of the severity and prognostic. Methods This analysis was conducted among 266 patients with AP treated in our hospital from January, 2017 to March, 2019. According to the severity of the condition, the patients were classified into severe acute pancreatitis(SAP) group, moderately severe acute pancreatitis(MSAP) group and mild acute pancreatitis(MAP) group, with the normal health examination person without disease as the control group. The demographic data and data of RDW were collected from all cases to evaluate the value of RDW in assessing the severity of AP. Results The patients with AP and the control subjects showed significant differences in RDW(P < 0.05). RDW was significantly higher in SAP patients than in non-MSAP patients(P < 0.05). Binary classification logistic regression analysis showed that RDW(P < 0.05, OR = 3.378) was a independent risk factor for AP. The area under the ROC curve of RDW for predicting AP and SAP respectively is 0.712 and 0.840. Conclusion RDW is a useful indicator for evaluation of the severity and prognostic of acute pancreatitis.