温郁金抗新型冠状病毒肺炎(COVID-19)的机制探索

Exploring mechanism of Curcuma wenyujin against COVID-19

新型冠状病毒肺炎(COVID-19)具有流行性广、传染性强、发病急骤和病情危重等特点,目前对于COVID-19主要采用中西医结合治疗方法,临床效果显著,凸显中医药在抗病毒方面的优势。早期大量药理药效学和临床研究证实温郁金具有显著抗病毒作用,对病毒性肺炎、上呼吸道感染等呼吸系统疾病疗效确切。此外,温郁金还具有一定抗肺纤维化作用,提示其可能会对由COVID-19引发的肺损伤有缓解或治疗作用。通过对温郁金抗病毒的化学成分、药理作用、机制研究和临床应用进行总结梳理,并从中医角度分析COVID-19的病因机制和辨证治法,以期为温郁金临床治疗COVID-19和后续相关药物研发提供参考。

Coronavirus disease 2019(COVID-19)has the characteristics of widespread epidemic,strong infectivity,rapid onset and critical illness.At present,many hospitals adopt integrated Chinese and Western medicine treatment methods,which have significant clinical effects,highlighting the antiviral effect of traditional Chinese medicine in.A large number of early pharmacological and pharmacodynamic and clinical research results have confirmed that medicinal plants Curcuma wenyujin has a significant antiviral effect,and it is effective for respiratory diseases such as viral pneumonia and upper respiratory tract infection.In addition,medicinal plants C.wenyujin also has a certain anti-pulmonary fibrosis effect,suggesting that it may alleviate or treat lung injury caused by COVID-19.Through summarizing and combing the chemical composition,pharmacological action,mechanism research and clinical application of antiviral of medicinal plants C.wenyujin,and analyzing the etiology mechanism and dialectical treatment of COVID-19 from the perspective of traditional Chinese medicine,with a view to providing a reference for the clinical treatment of COVID-19 infection and subsequent related drug development.