白芍炮制的历史沿革及化学成分、药理作用研究进展

Research progress on processing history evolution,chemical constituents and pharmacological action of Paeoniae Radix Alba

白芍为临床常用的补血调经药,在《神农本草经》中列为上品,炮制方法有净制、切制、加辅料制等,目前主流的炮制方法为酒制及炒制,其化学成分主要有单萜类、三萜类、黄酮类等。现代研究表明,白芍具有保护心血管、抗炎、抗氧化等作用。对古代本草、医籍,现代药典、地方中药饮片炮制规范等进行了查阅、分析、整理,从白芍的性能、功用及炮制历史沿革等方面进行综述,同时对其现代炮制工艺、化学成分、药理研究等展开论述,以期为白芍的相关研究提供参考。

Paeoniae Radix Alba(PRA)is a clinically commonly used drug for tonifying blood and regulating meridians,which was listed as one of the highest grade herb in Shengnong's Classic of Materia Medica.The main chemical constituents of PRA are monoterpenes,triterpenes and flavonoids,and its processing methods are cleansing,cutting,adding auxiliary materials,etc.At present,the mainstream processing methods are stir-frying or stir-frying with wine.Modern studies have shown that PRA has the effects of protecting cardiovascular,anti-inflammatory and anti-oxidant.In this paper,we consulted with the ancient Chinese materia medica and ancient Chinese medical book,analyzed the local traditional Chinese medicine slices processing norms and modern pharmacopoeia.Meanwhile,we reviewed the history of PRA in function and processing,and discussed the modern processing technology,chemical composition and pharmacological research in some extent.We hope it can be helpful for some related research of PRA.