摘要
探索了在路易斯酸催化下,三氟甲基酰腙与三甲基氰硅烷的1,2-加成反应,得到了一系列含有三氟甲基的氰基酰肼类化合物.该方法具有反应条件温和、操作简单、产率高等特点,为合成结构多样的含三氟甲基的酰肼类化合物提供了一种有效的方法.
The Lewis acid catalyzed 1,2-addition reaction of trifluoromethylated acylhydrazones with trimethylsilyl cyanide was investigated,and a series of cyanohydrazide compounds containing trifluoromethyl group were afforded in high yield.The method could be easily operated in mild reaction conditions,which provides an efficient method for the synthesis of trifluoromethylated hydrazides with structural diversity.
作者
徐炜刚
黄丹凤
王克虎
赵芳霞
赵转霞
虎永琴
苏瀛鹏
胡雨来
Xu Weigang;Huang Danfeng;Wang Kehu;Zhao Fangxia;Zhao Zhuanxia;Hu Yongqing;Su Yingpeng;Hu Yulai(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第4期922-929,共8页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21662030,21861033)资助项目.
关键词
三氟甲基酰腙
三甲基氰硅烷
酰肼
氰基化反应
trifluoromethylated acylhydrazones
trimethylsilyl cyanide
acylhydrazides
hydrocyanation
