摘要
从Ug’s胺出发通过4步化学反应合成了一种新的手性PNN三齿配体indan-f-amphox(该配体为f-amphox的姊妹配体),并将其用于铱催化的β-芳基β-酮酸酯的不对称氢化反应,结果显示Ir(Ⅲ)-indan-f-amphox催化剂对该类反应具有非常高的反应活性和立体选择性(对应选择性最高99%,转化数高达10000),适用于多种β-芳基β-酮酸酯.
A new chiral tridentate PNN ligand, indan-f-amphox(a sister ligand of f-amphox), was synthesized and applied in iridium-catalyzed asymmetric hydrogenation of β-aryl β-ketoesters. A wide range of β-aryl β-ketoesters are reduced using an Ir(III)-indan-f-amphox catalyst with excellent enantioselectivities and reactivities(up to 99% ee, TON=10000).
作者
古国贤
胡杨
刘绍东
董秀琴
张绪穆
Gu Guoxian;Hu Yang;Liu Shaodong;Dong Xiu-Qin;Zhang Xumu(School of Chemical Engineering and Technology,Tianjin Key Laboratory of Chemical Process Safety,Hebei University of Technology,Tianjin 300130,China;College of Chemistry and Molecular Science,Wuhan University,Wuhan 430072,China;Department of Chemistry,Rutgers,The State University of New Jersey,Piscataway,NJ,08854,USA;Department of Chemistry,Southern University of Science and Technology,Shenzhen,Guangdong 518055,China)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第4期997-1002,共6页
Chinese Journal of Organic Chemistry
基金
深圳市科创委自由探索基金(No.JCYJ20170817104853520)资助项目.
