髓源性抑制细胞在急性白血病中的表达及临床意义

Expression and clinical significance of myeloid suppressor cells in acute leukemia

目的研究外周血髓源性抑制细胞(MDSCs)在急性B淋巴细胞白血病中(B-ALL)的表达及临床相关性。方法收集85例确诊B-ALL患者(缓解组34例,未缓解组51例)和15例健康对照者,采用流式细胞术(FCM)检测外周血中MDSCs的表达水平。结果未缓解组M-MDSCs水平高于缓解组及健康对照组(P<0.05);未缓解组及缓解组G-MDSCs水平均高于健康对照组(P<0.05),且未缓解组G-MDSCs水平高于缓解组(P<0.05);高危组M-MDSCs表达水平高于中危组(P<0.05);有中枢侵犯的B-ALL患者较无中枢侵犯的G-MDSCs升高(P<0.05);与预后良好患者相比,预后不良患者M-MDSCs水平升高(P<0.05);在G-MDSCs中,预后不良及中间组均高于预后良好组(P<0.05)。结论 B-ALL患者外周血中MDSCs的水平变化可能与该病的发生发展密切相关,且对判断患者预后存在一定价值。

Objective To study the expression and clinical relevance of peripheral blood myeloid-derived suppressor cells(MDSCs) in Acute B lymphoblastic leukemia(B-ALL).Methods Eighty-five patients with confirmed B-ALL and fifteen healthy controls were enrolled. Flow cytometry(FCM) was used to detect the expression of MDSCs in peripheral blood.Results The level of M-MDSCs in the un-remission group was higher than that in the remission group and the healthy control group(P<0.05).The G-MDSCs levels in the un-remission group and the remission group were higher than those in the healthy control group(P<0.05), and the levels of G-MDSCs in the un-remission group were higher than those in the remission group(P<0.05). The expression level of M-MDSCs in high-risk group was higher than that in middle-risk group(P<0.05). B-ALL patients with central invasion had significantly higher G-MDSCs than those without central invasion(P<0.05).Compared with patients with good prognosis, the level of M-MDSCs increased in patients with poor prognosis(P<0.05). In G-MDSCs, poor prognosis and intermediate groups were higher than good prognosis group(P<0.05).Conclusion The level of MDSCs in peripheral blood of patients with B-ALL may be closely related to the occurrence and development of the disease, and it has certain value for judging the prognosis of patients.